2-Propanone, reaction products with diphenylamine

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

06/02/2018 to 07/02/2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

ISO 13320:2009 “Particle Size Analysis – Laser Diffraction Methods”, 2009

Deviations:

not specified

Principles of method if other than guideline:

The test is conducted in accordance with CIPAC MT 187 “Particle Size Analysis by Laser Diffraction”, Handbook K, 2007.

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

counted distribution

Specific details on test material used for the study:

No further details specified in the study report.

Mass median aerodynamic diameter:

>= 25.165 - <= 25.961 µm

Geometric standard deviation:

2.573

Key result

Percentile:

D50

Mean:

24.15 µm

St. dev.:

0.297

Full Test Results

	RUN1	RUN2	RUN3	RUN4	RUN5	Average**
Volume weighted mean	31.022	31.018	30.938	30.798	30.690	30.893
Median	24.418	24.442	24.173	23.684	23.882	24.120
Mode	28.194	28.144	27.525	26.366	26.955	27.447
MMAD*	25.945	25.971	25.685	25.165	25.376	25.629
d10 – 10% of material is <	7.096	7.080	7.047	6.847	6.938	7.000
d50 – 50% of material is <	24.418	24.442	24.173	23.684	23.882	24.120
d90 – 90% of material is <	65.212	65.161	65.242	65.860	65.022	65.297

All results are in μm

*Mass median aerodynamic diameter

**Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

17.37 % by volume of sample was seen to be < 10.00 μm

 

Standard Deviation Results

Run No.	1	2	3	4	5	STDVP	%STDVP
d10 – 10% of material is <	7.096	7.080	7.047	6.847	6.938	0.095	1.4
d50 – 50% of material is <	24.418	24.442	24.173	23.684	23.882	0.297	1.2
d90 – 90% of material is <	65.212	65.161	65.242	65.860	65.022	0.290	0.4
d15.78 – 15.78 % of material is <	9.501	9.509	9.423	9.153	9.287	0.137	1.5
GSD	2.570	2.570	2.565	2.588	2.572	0.008	0.3
MMAD	25.945	25.971	25.685	25.165	25.376	0.316	1.2

GSD = Geometric standard deviation of the lognormal particle size distribution (calculated from d50/d15.78)

STDVP = standard deviation of the population

%STDVP = percentage standard deviation of the population

 

Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.

Conclusions:

Particle Size Analysis using dry powder module (DPM) Average (μm)
Volume weighted mean 30.893
Median (d.50) 24.150
MMAD (Mass Median Aerodynamic Diameter) 25.629

Executive summary:

To characterise the particle size distribution of the powder. The analysis is conducted initially using a visual microscope and is then undertaken more formally using a Laser Diffraction Particle Size Analyser.

 

The test is conducted in accordance with ISO 13320:2009 “Particle Size Analysis – Laser Diffraction Methods”, 2009.

 

Using the identified parameters, the particle size was analysed over the range 0.02 μm to 2000 μm.

 

Particle Size Analysis using dry powder module (DPM)	Average (μm)
Volume weighted mean	30.893
Median (d.50)	24.150
Mode	27.447
MMAD (Mass Median Aerodynamic Diameter)	25.629
10 % of material is <	7.000
50 % of material is <	24.120
90 % of material is <	65.297
by volume of sample was seen to be < 10.00 μm	17.37%

 

Description of key information

 

Particle Size Analysis using dry powder module (DPM)	Average (μm)
Volume weighted mean	30.893
Median (d.50)	24.150
MMAD (Mass Median Aerodynamic Diameter)	25.629

 

Additional information

To characterise the particle size distribution of the powder. The analysis is conducted initially using a visual microscope and is then undertaken more formally using a Laser Diffraction Particle Size Analyser.

Using the identified parameters, the particle size was analysed over the range 0.02 μm to 2000 μm.

 

Particle Size Analysis using dry powder module (DPM)	Average (μm)
Volume weighted mean	30.893
Median (d.50)	24.150
Mode	27.447
MMAD (Mass Median Aerodynamic Diameter)	25.629
10 % of material is <	7.000
50 % of material is <	24.120
90 % of material is <	65.297
by volume of sample was seen to be < 10.00 μm	17.37%