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Diss Factsheets
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EC number: 701-204-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 June 2020 - 24 August 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- The determination was carried out by the flask method, using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Batch: 1000352370
- Key result
- Water solubility:
- < 0.051 mg/L
- Incubation duration:
- > 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- ca. 6
- Details on results:
- PRELIMINARY TEST
The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was less than 5.27 x10^-5 g/L. The solution had a pH of 6.0.
MEAN CONCENTRATION
Less than 5.15 x 10^-5 g/L at 20.0 ± 0.5 ºC
DISCUSSION
On completion of the equilibration period, the samples were clear and colourless with excess, undissolved test item present. After filtration, the filtrates were visually observed to be clear, colourless, free from un-dissolved test item and with no definitive Tyndall beam effect.
The ion masses chosen for the analysis were used to represent the whole test item with it being a complex mixture and monitoring all components would not be practical; they were chosen from significant masses present in the mass spectrum of the test item.
The standard at 1.03 mg/L was excluded from calibration curve as it was considered to be inconsistent with the other standards and significantly affected the correlation. As the samples and matrix blank peak areas were less than that of the lowest standard, not including the 1.03 mg/L standard was considered to have no effect.
The sample and matrix blank generated very similar chromatograms. It was not confirmed if this was from the blank being contaminated or a background response. A fresh aliquot of the matrix blank was subsequently re-injected and still had similar chromatography so confirmed sample mix-up wasn’t the cause. The mass spectrum of the main peaks was like that of the mass spectrum of the corresponding peaks in the standards. Even so, the total peak area of the samples was less than that of the least concentrated standard (5.15 x 10^-5 g/L) and therefore, the results were reported as limit values based on the concentration of this standard. It is also noted that the preliminary test matrix blank and sample had chromatograms with significantly smaller peaks than those of the definitive test. - Conclusions:
- The water solubility of the test item has been determined to be less than 5.15 x 10-5 g/L of solution at 20.0 ± 0.5 °C.
- Executive summary:
The determination was carried out by the flask method, using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Reference
Description of key information
The water solubility of the test item has been determined to be less than 5.15 x 10-5 g/L of solution at 20.0 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.051 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item has been determined to be less than 5.15 x 10-5 g/L of solution at 20.0 ± 0.5 °C.
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