Registration Dossier
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EC number: 701-204-9 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 June 2020 - 24 August 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 30 °C
- pH:
- ca. 3
- Details on results:
- Mean log10 Pow: >6.5
Partition coefficient: >3.16 x 10E6 (see attached report for details)
DISCUSSION
The result from the preliminary test indicated that the HPLC method was suitable for determination of partition coefficient for this test item.
The mobile phase was adjusted to pH 3 to ensure any protonated nitrogen species (amines) in the test item would not have any significant secondary interaction with anionic silanol groups on the stationary phase of the column. - Conclusions:
- The partition coefficient of the test item has been determined to be greater than 3.16 x 10E6, log10 Pow >6.5.
- Executive summary:
The determination was carried out by the HPLC Method, using a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The test system consisted of a high performance liquid chromatograph with an appropriate detector. A reverse phase HPLC column with a very low percentage of polar groups was used and the mobile phase contained at least 25% aqueous phase.
The partition coefficient of the test item has been determined to be greater than 3.16 x 10^6, log10 Pow >6.5.
Reference
Description of key information
The partition coefficient (log Pow) of EC n° 701 -204 -9 has been evaluated using the HPLC method (OECD 117). Log Pow (weighted average) of >6.5 has been determined using polycyclic aromatic hydrocarbons as retention time calibrants.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.5
- at the temperature of:
- 30 °C
Additional information
The partition coefficient (log Pow) of EC n° 701-204-9 has been evaluated using the HPLC method (OECD 117).
The partition coefficient of the test item has been determined to be greater than 3.16 x 106, log10 Pow >6.5.
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