Registration Dossier
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EC number: 204-145-2 | CAS number: 116-53-0
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Reference:
- Composition 0
- Objective of study:
- metabolism
- Test material information:
- Composition 1
- Species:
- other: mammals
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 3rd:
Reference
Description of key information
Based on the metabolism via beta-oxidation it can reasonably be assumed that 22 -methylbutyric acid has no bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The branched-chain acids alkylated in alpha-position are metabolized via ß-oxidation in the longer branched-chain,
followed by cleavage to yield linear acid fragments, which are completely metabolized in the fatty acid pathway or the
tricarboxylic acid cycle. Beta-oxidation of 2 -methylbutyric acid has been observed in guinea-pigs in vivo.
Longer branched-chain acids may undergo omega-oxidation to yield diacids, which may undergo further oxidation and
cleavage.
2-Methylbutyric acid occurs endogenously as coenzyme-A intermediate in the human metabolism of the amino acid
isoleucine and undergoes complete conversion within common metabolic pathways (e.g. citric cycle).
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