Registration Dossier

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics in vivo
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Reference:
Composition 0
Objective of study:
metabolism
Test material information:
Composition 1
Species:
other: mammals
Toxicokinetic parameters:
half-life 1st:
Toxicokinetic parameters:
half-life 2nd:
Toxicokinetic parameters:
half-life 3rd:

Description of key information

Based on the metabolism via beta-oxidation it can reasonably be assumed that 22 -methylbutyric acid has no bioaccumulation potential.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The branched-chain acids alkylated in alpha-position are metabolized via ß-oxidation in the longer branched-chain,
followed by cleavage to yield linear acid fragments, which are completely metabolized in the fatty acid pathway or the
tricarboxylic acid cycle.  Beta-oxidation of 2 -methylbutyric acid has been observed in guinea-pigs in vivo.


Longer branched-chain acids may undergo omega-oxidation to yield diacids, which may undergo further oxidation and
cleavage.

2-Methylbutyric acid occurs endogenously as coenzyme-A intermediate in the human metabolism of the amino acid
isoleucine and undergoes complete conversion within common metabolic pathways (e.g. citric cycle).