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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 November 2017 to 23 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: Knudsen cell
Test material information:
Composition 1
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0 Pa
Key result
Temp.:
50 °C
Vapour pressure:
0.002 Pa

- The vapour pressure was measured in the temperature range of 30 to 100 °C. The measured vapour pressures at the corresponding temperatures are listed in Table 1. After the measurement a mass loss of approx. 4 % (w/w) was determined.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature / °C

Vapour pressure / hPa

30

2.3 × 10 -6*

40

8.3 × 10 -6*

50

1.8 × 10-5

60

3.7 × 10-5

70

8.5 × 10-5

80

1.4 × 10-4

* = Below the recommended range for this method

- The values for 20, 25 and 50 °C are calculated, using the Antoine constants A, B and C as shown in Table 2.

The vapour pressures measured at 30 °C and 40 °C respectively were not included in the linear regression because they were below the recommended range for this method.

Table 2: Antoine parameters and extrapolated vapour pressures

T / °C

p / hPa

log (p/hPa) = A + B/(C+T[°C])

20

1.4× 10 -6

A = 6.12537

25

2.2× 10 -6

B = -3514.08

50

1.8× 10-5

C = 273.15

The following vapour pressure values for the test material were extrapolated from the experimental data.

Table 3: Final Results

T / °C

p / hPa

p / Pa

20

1.4× 10 -6

1.4× 10 -4

25

2.2× 10 -6

2.2× 10 -4

50

1.8× 10-5

1.8× 10-3

Conclusions:
Under the conditions of this study, the vapour pressure of the test material was 1.4 x 10^-4 Pa, 2.2 x 10^-4 Pa and 1.8 x 10^-3 Pa at 20, 25 and 50 °C, respectively.
Executive summary:

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4, under GLP conditions.

The vapour pressure was examined using the effusion method with the Knudsen cell. The vapour pressure was measured in the temperature range of 30 to 100 °C.

After the measurement a mass loss of approx. 6 % (w/w) was determined. The values for 20, 25 and 50 °C were calculated, using the Antoine constants A, B and C.

Under the conditions of this study, the vapour pressure of the test material was 1.4 x 10^-4 Pa, 2.2 x 10^-4 Pa and 1.8 x 10^-3 Pa at 20, 25 and 50 °C, respectively.

Description of key information

Under the conditions of this study, the vapour pressure of the test material was 1.4 x 10^-4 Pa, 2.2 x 10^-4 Pa and 1.8 x 10^-3 Pa at 20, 25 and 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The vapour pressure was examined using the effusion method with the Knudsen cell. The vapour pressure was measured in the temperature range of 30 to 100 °C.

After the measurement a mass loss of approx. 6 % (w/w) was determined. The values for 20, 25 and 50 °C were calculated, using the Antoine constants A, B and C.

Under the conditions of this study, the vapour pressure of the test material was 1.4 x 10^-4 Pa, 2.2 x 10^-4 Pa and 1.8 x 10^-3 Pa at 20, 25 and 50 °C, respectively.