Registration Dossier
Registration Dossier
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EC number: 947-623-2 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Workers - Hazard for the eyes
Additional information - workers
DNELs for acute exposure (systemic effects)
MSP/TSP/DSP is not classified as hazardous for acute toxicity. According to REACH guidance Appendix R.8-8 it is therefore not necessary to derive acute DNEL values.
DNELs for acute and long-term exposure (local effects)
MSP/TSP/DSP is not classified as irritating to skin or eyes, or sensitising. It is therefore neither possible nor appropriate to derive acute or long-term DNEL values for local effects.
DNELs for long-term exposure (systemic effects)
Inhalation
No repeat-dose inhalation toxicity study is available for MSP/TSP/DSP. It is therefore not possible to quantify the long-term inhalation DNEL. However, since the substance is a viscous liquid which is not expected to generate aerosols during process or use as an intermediate, and that the vapor pressure estimated using an EpiSuite model was 6.52 x 10E-12 mmHg (i.e., 8.7 x 10E-10 Pa) at 25°C and therefore considered negligible, no hazard is expected by inhalation exposure from use as an intermediate.
Dermal
No repeat-dose dermal toxicity study is available for MSP/TSP/DSP and no data are available on dermal absorption. It is therefore not possible to quantify the long-term dermal DNEL. However, absence of any evidence of toxicity in a limit dose of 5000 mg/kg in an acute dermal toxicity study indicates that no hazard would arise from brief intermittent dermal exposure from use as an intermediate.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
As the test substance is used as an intermediate, the derivation of DNELs for general population is not considered appropriate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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