Registration Dossier
Registration Dossier
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EC number: 921-136-5 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Resorption
Because of the molecular structure, low molecular weight (358 g/mol) and and high octanol-water partition coefficient (>6.5), resorption of the test item via the gastrointestinal tract is considered to be unlikely. After single treatment of rats with the test item at a dose of 2000 mg/kg bw no signs of toxicity were observed (acute oral: key study). A repeat dose toxicity study with rats showed no relevant systemic effects after oral administration of 1000 and 300 or 100 mg/kg bw/d. Effects included increased body weight and water consumption and slight reversible liver findings in the histpathological evaluation at 1000 mg/kg bw/d. From these effects it can be concluded that the compound shows poor resorption after oral administration.
Distribution
Due to the low water solubility and the high octanol/water-coefficient, in combination with the low molecular weight permeation of membranes is assumed to be possible. The toxicological effects found in the repeat dose toxicity study (28d: key study) clearly show that this compound distributes poorly throughout the body after oral uptake and is thus systemically available only at very low level.
Metabolism and Excretion
Specific information on the metabolism and excretion of the substance is not available. Metabolism of the compoundd in the liver can be assumed, because reversible response was found in the histopathology evaluation of the liver that could be considered as a result of a metabolic adaptation (28d: key study). Because of the reversibility of the observed effects (e.g. on liver), the substance is most likely eliminated from the body. Due to the molecular properties of the test item, excretion via the kidneys is considered to be the main route of elimination.
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