Registration Dossier
Registration Dossier
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EC number: 210-723-5 | CAS number: 622-20-8
Endpoint summary
Administrative data
Description of key information
Guideline acute oral toxicity study in rats indicated a low- moderate order of acute toxicity.
Key value for chemical safety assessment
Additional information
Acute Oral Toxicity
An acute oral toxicity study was conducted according to Guideline OECD 420. The animal treated at a dose level of 2000 mg/kg was killed for humane reasons. Signs of systemic toxicity noted in the animal treated at a dose level of 2000 mg/kg were clonic convulsions, exophthalmos, increased salivation, dehydration, pilo-erection and decreased respiratory rate. Abnormalities noted at necropsy of the animal treated at a dose level of 2000 mg/kg were patchy pallor of the liver, epithelial sloughing of the gastric mucosa and hemorrhage of the non-glandular epithelium of the stomach. There were no deaths and clinical signs noted at a dose level of 300 mg/kg. The acute oral median lethal dose (LD50) of the test item in the female Wistar strain rat was estimated to be in the range of 300 - 2000 mg/kg body weight.
Justification for classification or non-classification
Based on an acute oral LD50 value of 300-2000 mg/kg for female Wistar strain rats in a key study (OECD 420, Klimisch score1), 1,1'-[ethane-1,2-diylbis(thio)]bisbenzene is considered to be in hazard category 4 for acute toxicity by the oral route of exposure under EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 and the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS). This category carries the signal word of "warning" and and hazard statement as "harmful if swallowed".
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