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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Calculation of the combined chronic toxicity values of individual alkyl lactates (chVs) based on ECOSAR predicted ChVs for Ceraphyl 31.
Principles of method if other than guideline:
Calculation based on ECOSAR v1.1 Class-specific Estimations
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
other: QSAR calculations
Key result
Dose descriptor:
other: ChV = 10^([log (LOEC x NOEC)]/2)
Effect conc.:
0.093 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
not specified
Remarks on result:
other: Ester based
Details on results:
ECOSAR v1.1 Class-specific Estimations:
Chronic values for alkyl lactates in Ceraphyl 31
C12 C14 C16
Invertebrates 0.427 0.086 0.017
C12 C14 C16
C12 composition 0.6 0.3 0.1

combined ChV - Invertebrates 0.093 mg/L

Estimation of the chronic value of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters for invertebrates:

Calculated based on QSAR values for Ester Toxicity:

Lactate ChV 1/ChV f f/ChV
Dodecyl lactate 0.427 2.342 0.60 1.405
Tetradecyllactate 0.086 11.63 0.30 3.488
Hexadecyllactate 0.017 58.82 0.10 5.882
Σf/ChV 10.78

ChV ofPropanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters 

0.093

f= estimated average fraction of chemical in mixtures

Description of key information

Chronic value (ChV) calculated based on QSAR estimated individual ChV values for the C12, C14 and C16 lactates being the main constituents of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.093 mg/L

Additional information

Estimation of the chronic value of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters for invertebrates:

Calculated based on QSAR values for Ester Toxicity:

Lactate ChV 1/ChV f f/ChV
Dodecyl lactate 0.427 2.342 0.60 1.405
Tetradecyllactate 0.086 11.63 0.30 3.488
Hexadecyllactate 0.017  58.82 0.10 5.882
Σf/ChV 10.78

ChV ofPropanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters 

0.093

f= estimated average fraction of chemical in mixtures