Registration Dossier
Registration Dossier
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EC number: 305-203-0 | CAS number: 94349-84-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Hops and hop extracts are increasingly being investigated for their beneficial health effects.
• Hop extract itself is not acutely toxic (LD50 >2,000 mg per kg bw for most hop extracts; potentially 1,000 – 2,300 mg per kg bw for β-acid-enriched extracts).
• The bitter acids (α-, β- and iso-α-acids are thought to be metabolised principally by phase I, leading to oxygenated derivatives that are similar to oxygenated compounds found in aged hops and aged beer. Rabbit and human data have shown that iso-α-acids have a short half-life.
• Oxygenated derivatives, known as matured hop bitter acids, have themselves been trialled as therapeutic agents in a human trial, and were considered to be safe over the 12-week period.
• Taken together, these data suggest that further animal studies on hop toxicokinetics are not warranted. In view of the growing interest in hop-derived compounds as possible therapeutic substances, more information on safety and toxicology will emerge as new therapeutic target compounds are tested.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 80
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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