Reaction mass of 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride and 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium chloride dihydrate

Oxidising properties

Link to relevant study record(s)

Reference

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 Oct - 14 Oct 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.17 (Oxidising Properties (Solids))

Version / remarks:

adopted in 2008

Deviations:

no

GLP compliance:

no

Specific details on test material used for the study:

Storage conditions: ambient temperature (10 to 30 °C), dry

Contact with:

powdered cellulose

Sample tested:

test mixture as specified

Remarks:

test item/cellulose 2:1

Parameter:

preliminary test

Remarks on result:

other: could not be ignited, only charring seen

Sample tested:

test mixture as specified

Remarks:

barium nitrate/cellulose 2:1

Parameter:

preliminary test

Remarks on result:

other: 3 test mixtures burned down completely in 67, 70 and 66 s

Sample tested:

reference mixture as specified

Remarks:

barium nitrate and cellulose with different wt. % oxidizer

Parameter:

maximum burning rate

Result:

1.61 mm/s

Remarks on result:

other: result found for mixture with 60 wt. % oxidizer

Sample tested:

test mixture as specified

Remarks:

cellulose with 10 and 20 wt % test item

Parameter:

burning time of reaction over a distance of 200 mm

Remarks on result:

other: mixture extinguished in preliminary burning phase

Sample tested:

test mixture as specified

Remarks:

cellulose with 30 and 60 wt % test item

Parameter:

burning time of reaction over a distance of 200 mm

Remarks on result:

other: mixture could not be ignited, local charring

Sample tested:

test mixture as specified

Remarks:

cellulose with 90 wt % test item

Parameter:

burning time of reaction over a distance of 200 mm

Remarks on result:

other: mixture could not ignited, charring and swelling

Results
Preliminary test
Three test mixtures of test item and cellulose 2:1 could not be ignited by the flame. Only local charring was seen.
Three test mixtures of barium nitrate/cellulose 2.1 burned down completely in 67, 70 and 66 s, respectively.

Main Test
Four tests were done for the reference mixture (barium nitrate and cellulose) with 50, 55, 60 and 70 wt. % oxidizer (barium nitrate).

Table 1 – Burning times and rates of reference mixtures

Barium nitrate [wt. %]	Burning time over 200 mm [s]	Burning rate [mm/s]
50	169	1.18
55	130	1.54
60	124	1.61
70	187	1.07

The highest burning rate of 1.61 mm/s was found for the mixture with 60 wt. % oxidizer.

Mixtures of test item with cellulose were prepared in between 10 and 90 wt. % of the test item (Table 2).

Table 2 – Burning times and rates of test item mixtures

Test item [%]	Burning time over 200 mm [s]	Burning rate [mm/s]
10	Mixture extinguished in the preliminary burning phase	---
20
30	Mixture could not be ignited, local charring
60
90	Mixture could not be ignited, charring and swelling

 

As the maximum burning rate of the test item and cellulose mixtures is lower than the maximum burning rate of the reference mixture, six tests were done only with the three mixtures (10, 20 and 30 wt. % of the test item) with the highest burning rates to verify these values (Table 3).

Table 3 – Burning times and rates of fastest test item mixtures

Test	t [s]	V [mm/s]	t [s]	V [mm/s]	t [s]	V [mm/s]
10%	Test item could not be ignited
20%
30%	Test item could not be ignited, local charring

 

Each mix was measured 6 times, no burning rate could be calculated.

The maximum burning rate of test item and cellulose mixtures was lower than that of the reference mixture of cellulose with barium nitrate (1.61 mm/s).

Conclusion
The test item has no oxidizing properties.

 

 

Description of key information

Non oxidizing solid (EU Method A.17.)

Key value for chemical safety assessment

Oxidising properties:

non oxidising

Additional information

The maximum burning rate of test item and cellulose mixture was lower than that of the reference mixture of barium nitrate and cellulose 2:1 (1.61 mm/s).

Justification for classification or non-classification

 The available data on oxidizing properties of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification: The maximum burning rate of the test mixture was less than that of the reference mixture (barium nitrate and cellulose 2:1) in a test according to the EU method A.17.