Reaction mass of 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride and 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium chloride dihydrate

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 Oct 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Version / remarks:

adopted in 2008

Deviations:

no

GLP compliance:

no

Specific details on test material used for the study:

Storage conditions: ambient temperature (10 to 30 °C), dry

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

Results
Preliminary test
The test item could not be ignited with a flame, it showed charring in contact with the flame. Main test performance was not needed.

Conclusion: The test item is not a highly flammable solid.

Reference 2

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Reference 3

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Reference 4

Endpoint:

self-heating substances / mixtures

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Description of key information

Substance is not a highly flammable solid (EU Method A.10., Burning rate preliminary screening test).
No pyrophoricity.

No flammability on contact with water.

Not self-heating (auto-flammability study, EU Method A.16)

Key value for chemical safety assessment

Flammability:

not classified

Additional information

The flammability of the substance was determined according to EU Method A.10. Based on the chemical structure and experience in handling and use, pyrophoricity and flammability on contact with water are not expected . The substance is not self-heating based on the auto-flammability study up to 399 °C.

Justification for classification or non-classification

The available data on flammability of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification: No propagation of burning in a test according to EU Method A.10. Based on the chemical structure and experience in handling and use, pyrophoricity and flammability on contact with water are not expected. A preliminary test excludes self-heating of the substance up to 399 °C.