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EC number: 240-941-6 | CAS number: 16898-52-5
Corrosive, based on results of one of two in vivo skin irritation or corrosion studies.
None of the animals exhibited any signs of skin corrosion at any of the test sites. The test substance is not considered corrosive to the skin of albino rabbits according to the test study.
Signs of necrosis (irreversible corrosive damage to the skin) were present at the 24h and 72h observation period at all test sites. The test substance is considered a corrosive irritant to the skin of rabbits.
There are conflicting findings in the two in vivo studies on irritation/corrosion endpoints. The outcome of a guideline corrosion study in rabbits is "non-corrosive" at any of the three timepoints (3 m, 60 m and 4 h), with no adverse effects noted. In contrast, the skin irritation study (4 h) resulted in a finding of necrosis in all animals. The current in vivo skin irritation studies were conducted under conditions which are more stringent than those of the OECD 404 protocols on which GHS evaluation is based. The current irritation study used occlusive exposures (impermeable bandage), and applied material to abraded sites as well as intact sites, in 6 rabbits, with no observation period after 72 h post administration. The conflicting results of the two in vivo 4-hour exposure suggests a weight of evidence approach is indicated. A dermal acute toxicity study was undertaken in rabbits where the test material was applied for a 24 h occlusive exposure duration, with a finding of necrosis in all animals. In a guinea pig skin sensitisation test, necrosis was also observed after 6 h of occlusive patch exposures to undiluted test material. There are no known occupational accident reports involving skin corrosion or irritation in human workers. The substance has a pH in water of greater than 7, indicating alkaline properties. There are no known close structural analogues with relevant toxicity data. The evidence indicates that the test substance is a skin corrosive, classified as Category 1C. No in vivo eye irritation study exists, as severe damage is assumed based on corrosive properties.
A weight of evidence approach is used to interpret all known experimental data on skin irritation potential. The substance is classified as a skin corrosive, Category 1C. It is anticipated that the eye would also show severe damage after exposure, Cat 1.
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