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EC number: 638-734-4 | CAS number: 157248-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Resorption
Because of the molecular structure, low molecular weight and octanol-water partition coefficient (>5.7), resorption of the test item via the gastrointestinal tract is considered to be likely.
After single treatment of rats with the test item at a dose of 2000 mg/kg bw no signs of toxicity were observed (acute oral: key study).
Daily oral treatment by gavage of 100 and 300 mg/kg bw/d of the test item to rats according to the study design was tolerated whereas 1000/600 mg/kg bw/d was clinically not tolerated and lead to early sacrifice of 4 female animals. All doses (100, 300 and 1000 mg/kg bw/d) were clinically tolerated over a treatment period of 41 days in males. Slight effects were seen on motor activity, mean body weight, mean body weight gain and food consumption. In females 100 and 300 mg/kg bw/d were clinically tolerated over a treatment period of approximately up to 7 weeks. At 300 mg/kg bw/d females showed slight effects on mean body weight, mean body weight gain and food consumption and at 100 mg/kg bw/d females only showed a slight effect on mean body weight gain. In the surviving females of group 4 (1000/600 mg/kg bw/d) the mean body weight gain after dose reduction from 1000 to 600 mg/kg bw/d was strongly reduced body and the mean body weight at the beginning and end of treatment was nearly the same. According to the effects of in-life body weights, decreases terminal body weight were seen in 300 mg/kg bw/d females, 1000 mg/kg bw/d males and in the surviving 1000/600 mg/kg bw/d females at necropsy. In addition, decreases of absolute and relative liver weights were observed in 1000/600 mg/kg bw/d females, most likely as a consequence of the catabolic metabolism status. At histopathology, the following treatment-related and non-adverse alterations were noted in the liver of 1000 mg/kg bw/d males and surviving 1000/600 kg/kg/d females: multifocal hepatocellular necroses (both sexes), multifocal mononuclear infiltrates and reduced hepatocellular glycogen content (both females only). The 1000 mg/kg bw/d females that were prematurely sacrificed showed a decreased cellularity in the bone marrow and lymphoid depletion in the cortex of the thymus. Both findings were considered secondary to the moribund condition of the animals. Regarding reproduction parameters no treatment-related effects were noted at the clinically tolerated doses of 100 and 300 mg/kg bw/d. In conclusion, the no adverse effect level (NOAEL) regarding systemic toxicity and reproduction parameters is considered to be 300 mg/kg bw/d.
From these effects it can be concluded that the test item is resorbed after oral administration.
Distribution
Due to the low water solubility and the high octanol/water-coefficient, in combination with the low molecular weight, permeation of membranes is assumed to be possible. The toxicological effects found in the repeat dose toxicity study of the test item (OECD 422) clearly show that this compound is distributed throughout the body after oral uptake and is thus systemically available.
Metabolism and Excretion
Specific information on the metabolism and excretion of the substance is not available. From the OECD 422 study metabolism in the liver can be assumed as findings were observed in the liver. Due to the molecular properties, excretion via the kidneys is considered to be the main route of elimination.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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