Ethyl 4-dimethylaminobenzoate

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19 July 2016 to 16 March 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Atm. press.:

1 019 mBar

Decomposition:

yes

Decomp. temp.:

> 110 °C

Remarks on result:

not determinable

The DSC trace showed an endotherm at approximately 70 °C, consistent with the melting temperature, followed by a series of exotherms above approximately 110 °C which indicated decomposition of the test material and was consistent with the darkening noted during the preliminary assessment. The earlier endotherm noted at approximately 40 to 50 °C was considered to be due to either a small amount of residual solvent in the sample or the test material going through a different physical form before melting.

The broad endotherm at approximately 320 °C was considered to be due to boiling of the decomposed sample and this was also observed in the preliminary assessment. A brown residue was present in the crucible at the end of the test.

Conclusions:

Under the conditions of this study the boiling temperature of the test material was not determinable as the test material decomposed at temperatures above approximately 110 °C before boiling.

Executive summary:

The boiling temperature of the test material was determined in accordance with the standardised guidelines OECD 103 and EU Method A.2 under GLP conditions using differential scanning calorimetry (DSC).

Under the conditions of the study the boiling temperature of the test material was not determinable as the test material decomposed at temperatures above approximately 110 °C before boiling.

Description of key information

Under the conditions of this study the boiling temperature of the test material was not determinable as the test material decomposed at temperatures above approximately 110 °C before boiling.

Additional information

The boiling temperature of the test material was determined in accordance with the standardised guidelines OECD 103 and EU Method A.2 under GLP conditions using differential scanning calorimetry (DSC). The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of this study the boiling temperature of the test material was not determinable as the test material decomposed at temperatures above approximately 110 °C before boiling.