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EC number: 255-002-6 | CAS number: 40615-36-9
Table 1: Induction of Luciferase Activity – Overall Induction
* = significant induction according to Student’s t-test, p<0.05
In a dermal sensitisation study conducted according to OECD 442D with 4,4’-Dimethoxytrityl chloride (purity 100%) in DMSO, the sensitisation potential of the test item was assessed on the basis of the activation of keratinocytes using the in vitro KeratinoSens™. Cells were incubated with the test item for 48 h at 37 °C and later checked for luciferase activity.
Sensitisation was scored by measuring maximum luciferase activity induction (Imax), cell viability and EC1.5. For both experiment I and II, Imax was greater than a 1.5 fold increase, cell viability was greater than 70% and the value for EC1.5 was less than 1000 µM.
Therefore, in this study, the test item 4,4’-Dimethoxytrityl chloride is considered to be a skin sensitiser under UN GHS “Category 1”.
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