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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-01-11 to 2018-02-06
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Type of method:
column elution method
Test material information:
Composition 1
Water solubility:
3 mg/L
Conc. based on:
test mat. (dissolved fraction)
Incubation duration:
2 h
Temp.:
20 °C
pH:
6.8

Run 1 (25 mL/h): Regarding fractions 6 to 15 the solubility varied between 3.278 mg/L and 3.669 mg/L.

Average solubility: 3.429 mg/L (RSD: 3.7 %)

Table 1: Column elution method, Run 1 (25 mL/h); Test material amount used for coating: 50.83 mg

 Fraction no.  Approx. volume (mL)  pH  Cs (mg/L)
  Fraction 06  15.0  6.2  3.460
  Fraction 07  15.0  6.3  3.669
  Fraction 08  15.5  6.5  3.578
  Fraction 09  15.0  6.4  3.480
  Fraction 10  15.5  6.5  3.463
  Fraction 11  15.5  6.7  3.390
  Fraction 12  15.5  7.1  3.345
  Fraction 13  15.0  6.9  3.323
  Fraction 14  15.0  7.9  3.278
  Fraction 15 15.0  7.7 3.304

Run 2 (12.5 mL/h): Regarding fractions 06 to 15 the solubility varied between 2.481 mg/L and 2.711 mg/L

Average solubility: 2.564 mg/L (RSD: 3.0 %)

Table 2: Column elution method, Run 2 (12.5 mL/h); Test material amount used for coating: 51.23 mg

Fraction no.  Approx. volume (mL)  pH  Cs (mg/L)
  Fraction06  14.5  7.8  2.562
  Fraction 07  14.0  7.3  2.524
  Fraction 08  14.5  6.8  2.677
  Fraction 09  15.0  6.7  2.711
  Fraction 10  14.5  6.5  2.558
  Fraction 11  14.0  6.4  2.609
  Fraction 12  15.5  6.4  2.506
  Fraction 13  15.0  6.3  2.481
  Fraction 14  14.5  6.5  2.505
  Fraction 15 15.0  6.4  2.508

Mean value: The solubility Csof the test item 4,4’-Dimethoxytrityl chloride in distilled water at 20oC was 3.0 mg/L (RSD: 20.4 %)

The determined water solubilities for both runs show a repeatability of < 30 %, therefore the results of the two runs are considered to be in accordance.

At the end of each column elution experiment, there was still enough test item left on the surface of the glass beads at the end of all runs. There were no visible changes in the coating during the runs.

Conclusions:
The water solubility of 4,4’-Dimethoxytrityl chloride in double distilled found to be 3.0 mg/L at pH 6.8 and a temperature of 20 °C.
Executive summary:

The water solubility of 4,4’-Dimethoxytrityl chloride was determined in double distilled water according to the "column elution method" described in the European Commission Council regulation (EC) No 440/2008, Annex, Part A, A.6., OECD-guideline 105 and the EPA Product Properties Test Guideline OCSPP 830.7840 and found to be 3.0 mg/L at pH 6.8 and a temperature of 20 °C.

Description of key information

The water solubility of 4,4’-Dimethoxytrityl chloride in double distilled water was found to be 3.0 mg/L at pH 6.8 and a temperature of 20 °C.

Key value for chemical safety assessment

Water solubility:
3 mg/L
at the temperature of:
20 °C

Additional information