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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-01-19 to 2018-02-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Qualifier:
according to
Guideline:
other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
agglomerate
Type of distribution:
volumetric distribution
Test material information:
Composition 1
Mass median aerodynamic diameter:
12.8 µm
Percentile:
D50
Mean:
12.8 µm
Remarks on result:
other: Standard deviation not reported
Percentile:
D10
Mean:
4 µm
Remarks on result:
other: Standard deviation not reported
Percentile:
D90
Mean:
383.5 µm
Remarks on result:
other: Standard deviation not reported

The test item consisted of non-transparent particles which had a very strong tendency for agglomeration. The particles had a sticky behaviour and were electrostatically charged after sieving. A large part of the test item was present in form of agglomerates with a diameter above 1 mm. The aforementioned effects opposed a measurement via sieve analysis and influenced the results of the study using laser diffraction. Hence, the test item was sieved with a mesh size of 1000 µm. Only 43% (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.

Median particle size D (v, 0.5): 50% of particle volume or particle mass with lower particle diameter

1st test series: 11.8 µm

2nd test series: 13.9 µm

Average of median particle size: 12.8 µm

Particle size D (v, 0.1): 10% of particle volume or particle mass with lower particle diameter

1st test series: 3.8 µm

2nd test series: 4.2 µm

Average of the particle size: 4.0 µm

Particle size D (v, 0.9): 90% of particle volume or particle mass with lower particle diameter

1st test series: 327.9 µm

2nd test series: 439.1 µm

Average of the particle size: 383.5 µm

The particle size showed a polymodal distribution. Maxima were observed at approximately 0.8 µm, 8 µm, 80 µm and 400 µm. The maxima at 400 µm and 80 µm most likely corresponded to agglomerates.

Conclusions:
The particle size distribution of the test item 4,4’-Dimethoxytrityl chloride was determined by laser diffraction (light scattering):
Average of the median particle size D (v, 0.5): 12.8 µm
Average of the particle size D (v, 0.1): 4.0 µm
Average of the particle size D (v, 0.9): 383.5 µm
Executive summary:

The particle size distribution of the test item 4,4’-Dimethoxytrityl chloride was determined by laser diffraction (light scattering). A large part of the test item was present as agglomerates with a diameter above 1 mm. Hence, the test item was sieved with a mesh size of 1000 µm. Only 43% (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.

Average of the median particle size D (v, 0.5): 12.8 µm

Average of the particle size D (v, 0.1): 4.0 µm

Average of the particle size D (v, 0.9): 383.5 µm

Description of key information

The particle size distribution of the test item 4,4’-Dimethoxytrityl chloride was determined by laser diffraction (light scattering). A large part of the test item was present as agglomerates with a diameter above 1 mm. Hence, the test item was sieved with a mesh size of 1000 µm. Only 43% (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.

Average of the median particle size D (v, 0.5): 12.8 µm

Average of the particle size D (v, 0.1): 4.0 µm

Average of the particle size D (v, 0.9): 383.5 µm

Additional information