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EC number: 215-851-5 | CAS number: 1429-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The report was lacking in detail on animal husbandry and test material and individual irritation scores were not included.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- The report was lacking in detail on animal husbandry and test material.
- GLP compliance:
- no
Test material
- Reference substance name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- EC Number:
- 215-851-5
- EC Name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- Cas Number:
- 1429-50-1
- Molecular formula:
- C6H20N2O12P4
- IUPAC Name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- Test material form:
- not specified
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: 'albino'
- Details on test animals or tissues and environmental conditions:
- Not provided.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg of finely ground sample were placed in the conjunctival sac of the right eye of each rabbit. - Duration of treatment / exposure:
- The eyes were rinsed after 24 hours.
- Observation period (in vivo):
- 168 hours
- Number of animals or in vitro replicates:
- 2M, 1F
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Average maximum score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 31.6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- The compound was classified as a moderate eye irritant in male and female rabbits. The average maximum score was 31.6 out of possible 110 in one hour.
- Other effects:
- Discomfort was moderate immediately following application. Moderate discharge and erythema, mild edema, and mild corneal cloudiness developed within one hour. Iris clarity improved slightly overnight due primarily to some disappearance of corneal dullness. Discharge nearly ceased in three days. Iris clarity was normal within seven days. A slight degree of redness and edema remained.
Any other information on results incl. tables
Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Time point |
Score per animal |
Average |
60 min |
29/33/33 |
31.6 |
24 h |
24/31/29 |
28 |
48 h |
19/25/25 |
23 |
72 h |
13/20/18 |
17 |
120h |
8/13/10 |
10.3 |
168h |
4/6/6 |
5.3 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The average maximum score of 31.6 out of possible 110 at one hour is reported in a study which is equivalent to guideline but not compliant with GLP. Only total scores were included in the report, however the report states that iris effects had cleared by day 7 indicating that these must have been ≥1 within the 24-72 hour period which serves as the basis for classification. Together with the moderate effects of erythema, oedema and corneal dullness the study is used as weight of evidence to classify EDTMP-H as Category 2 eye irritant.
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