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Diss Factsheets
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EC number: 241-949-2 | CAS number: 18039-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- November from 06th to 20th, 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: unsuitable for the assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- 10 female rats were dosed with 5000 mg/kg body weight, once, by gavage. After the observation period of 14 days, the surviving animals were killed by O2 gas, dissected and examined macroscopically.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Fluorescent Brightener 371
- IUPAC Name:
- Fluorescent Brightener 371
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 172 - 186 g (mean 182 g).
- Fasting period before study: the animals were deprived of food for 16 hours before and 2 hours after treatment.
- Housing: the animals were kept in groups in plastic cages on wood shavings.
- Diet: Altromin 1324 (Altromin GmbH), ad libitum.
- Water: ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- A 25 % emulsion in water (25 g / ad 100 ml) was prepared.
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Ten rats
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the animals were weighed weekly.
- Necropsy of survivors performed: yes; the surviving animals were killed by O2 gas at the end of the follow-up period, dissected and examined macroscopically.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No animal died at the dose given.
- Clinical signs:
- other: About 60 minutes after the treatment, all animals showed squat position and hair retention. Forty minutes later, passivity, miosis, dilated eyelids, and increased lacrimation were observed. 24 hours post application, all animals were free from clinical sy
- Gross pathology:
- The section of animals killed after the end of the experiment was macroscopically without any special features.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- LD50 (females) > 5000 mg/kg bw
- Executive summary:
The substance was assessed for oral acute toxicity potential, using female rats. For the treatment, a 25 % emulsion in water (25 g/100 ml) was prepared and administered in the dosage of 5000 mg/kg body weight, once by gavage. After the observation period of 14 days, the surviving animals were killed by O2 gas, dissected and examined macroscopically.
No deaths occurred; about 60 minutes after the treatment, all animals showed squat position and hair retention. Forty minutes later, passivity, miosis, dilated eyelids, and increased lacrimation were observed. 24 hours post application, all animals were free from clinical symptoms. Body weight and body weight gain were normal. The section of animals killed after the end of the experiment was macroscopically without any special features.
Conclusion
LD50 (females) > 5000 mg/kg bw
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