Registration Dossier
Registration Dossier
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EC number: 225-443-9 | CAS number: 4851-50-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Based on the acute oral discriminating dose > 15000 mg/kg bw of 1,8-bis[(4-methylphenyl)amino]anthraquinone and the NOAELs of 1000 mg/kg bw in the Repeated Dose 28 Day Oral Toxicity Study in Rodents and the Combined Repeated Dose Toxicity Study and Reproductive/ Developmental Toxicity Screening Study with structural analogue substances, no hazard is identified for systemic toxicity.
1,8-bis[(4-methylphenyl)amino]anthraquinone is not irritating/corrosive to the skin and not irritating to the eyes and not skin sensitising. Therefore, for local effects no hazard is identified.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Based on the acute oral discriminating dose > 15000 mg/kg bw of 1,8-bis[(4-methylphenyl)amino]anthraquinone and the NOAELs of 1000 mg/kg bw in the Repeated Dose 28 Day Oral Toxicity Study in Rodents and the Combined Repeated Dose Toxicity Study and Reproductive/ Developmental Toxicity Screening Study with structural analogue substances, no hazard is identified for systemic toxicity.
1,8-bis[(4-methylphenyl)amino]anthraquinone is not irritating/corrosive to the skin and not irritating to the eyes and not skin sensitising. Therefore, for local effects no hazard is identified.
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