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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Deviations:
no
Principles of method if other than guideline:
In consideration of the relevance of granulometry study on toxicological assessment, only the size distributions of the sieved fraction < 100 µm were studied in detail.
GLP compliance:
no
Type of method:
microscopic examination
Type of particle tested:
primary particle
Type of distribution:
counted distribution
Mass median aerodynamic diameter:
3.98 µm
Key result
Percentile:
D50
Mean:
3.98 µm
Remarks on result:
other: spherical volume
No.:
#1
Size:
1 - 2 µm
Distribution:
21.79 %
No.:
#2
Size:
2 - 3 µm
Distribution:
26.71 %
No.:
#3
Size:
3 - 5 µm
Distribution:
27.55 %
No.:
#4
Size:
5 - 100 µm
Distribution:
23.96 %

Sieve Fraction (100 µm sieve):

- Weighted sample: 0.8205 g

- Weight fraction < 100 µm: 0.4253 g

- Sieve mass fraction < 100 µm: 51.83 %

The mass fraction < 100 µm was investigated by scanning eletron microscopy. The median aspect ration was 1.51.

The median diameter of the particle size is given for the fraction < 100 µm. The value of 3.98 µm was calculated for spherical particle and a value of 4.46 µm was calculated for cubical particle.

 Particle size  Spherical Volume [%]  Cubical Volume [%]
 < 4 µm (respirable)  4.76  5.29
 4 - 10 µm (thoracic)  31.53  34.15
 10 - 100 µm (inhalable)  63.71  60.56
 > 100 µm  0.00  0.00
 Median (diameter µm)  3.98  4.46
Conclusions:
The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 3.98 μm as spherical particles.
Executive summary:

According to OECD guideline 110, method B, the particle size distribution of was determined by scanning electron microscopy method for the sieved fraction (< 100 µm, 51.83 % of total sample) and presented on the basis of calculated mass fractions. The median diameter was 3.98 µm as spherical particles with the two main fractions of 31.53 and 63.71 % distributing in the range of 4-100 µm and hence the tested particles with sieved size smaller than 100 µm are mainly dominated by inhalable and thoracic fractions as defined in EU 481.

Description of key information

Mass fraction as spherical particles:


48,17% > 100µm


33,02% in 10-100 µm


16,34% in 4-10 µm


2,47% < 4 µm

Additional information

According to OECD guideline 110, method B, the particle size distribution of was determined by scanning electron microscopy method for the sieved fraction (< 100 µm, 51.83 % of total sample) and presented on the basis of calculated mass fractions. The median diameter was 3.98 µm as spherical particles with the two main fractions of 31.53 and 63.71 % distributing in the range of 4-100 µm and hence the tested particles with sieved size smaller than 100 µm are mainly dominated by inhalable and thoracic fractions as defined in EU 481.


The values presented above as key information were recalculated to represent the distribution in the total (non sieved) substance.