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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study meets generally acceptable scientific principles (mainly local effects were studied; no doses reported)
Cross-reference
Reason / purpose for cross-reference:
other: read-across target
Reference
Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Justification for type of information:
It is considered justified to utilise information on this substance in a read across approach since it is a potential metabolite of the registered substance.
Reason / purpose for cross-reference:
read-across source
Remarks on result:
not measured/tested
Critical effects observed:
not specified
Conclusions:
Drying of the skin was reported and on continuous exposure, cracking, furrowing and exfoliation of the epidermis. No systemic effects were noted without information of the scope of survey.
Executive summary:

It is considered justified to utilise information on n-butanol in a read across approach since it is a potential metabolite of the registered substance.

Butan-1-ol was applied to rabbit skin under occlusive conditions for 12* 5 h within 21 d. Mainly local effects were studied.

Drying of the skin was reported and on continuous exposure, cracking, furrowing and exfoliation of the epidermis. No systemic effects were noted without information of the scope of survey.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1949

Materials and methods

Principles of method if other than guideline:
Butan-1-ol was applied to rabbit skin under occlusive conditions for 12* 5 h. Mainly local effects were studied.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of treatment / exposure:
21 d
Frequency of treatment:
12 * 5 h within 21 d
Doses / concentrations
No. of animals per sex per dose:
no data

Results and discussion

Effect levels

Remarks on result:
not measured/tested

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Drying of the skin was reported and on continuous exposure, cracking, furrowing and exfoliation of the epidermis.

No systemical toxicity noted.

Applicant's summary and conclusion

Conclusions:
Drying of the skin was reported and on continuous exposure, cracking, furrowing and exfoliation of the epidermis. No systemic effects were noted without information of the scope of survey.
Executive summary:

Butan-1-ol was applied to rabbit skin under occlusive conditions for 12* 5 h within 21 d. Mainly local effects were studied.

Drying of the skin was reported and on continuous exposure, cracking, furrowing and exfoliation of the epidermis. No systemic effects were noted without information of the scope of survey.