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EC number: 213-156-1 | CAS number: 927-62-8
There are no experimental results for N,N-dimethylbutylamine itself known to exist.
However, several structurally related primary, secondary and tertiary alkylamines with saturated, short-chain ligands, were all tested negative in various screening tests (e.g. ear mouse swelling test) and guideline tests (guinea pig maximisation test, local lymph node assay). Evidence is as follows:
Saturated primary aliphatic amines:cyclohexylamine, hexylamine, n-octylamine, isopropylamine, 2-aminobutane) failed to produce an allergic response in screening test (e.g. mouse-ear swelling test) (Bingham et al. 2000). Also, N-Butylamine is reported to have been negative in a study of the potential of skin sensitisation (no primary source cited; Greim et al. 1998). No evidence of positive sensitization results was obtained I animal studies for isopropylamine, butylamine, octylamine, propylamine, 3-methoxy-, or 1-amino-2-propanol (OECD; 2011; primary references in the SIAR (at present not available) and in Iuclid Dossiers).
Saturated secondary aliphatic amines:diethylamine was negative in a mouse ear swelling test (Virginia Chemicals, 1987)
Saturated tertiary aliphatic amines:dimethylethylamine was negative in a guinea pig maximization test (similar to OECD 406). dimethylcyclohexylamine was negative in a guinea pig maximization test (similar to OECD 406), and in a mouse local lymph node assay (OECD 429) (OECD, 2012).
Based on the above it is anticipated that saturated primary, secondary, and tertiary aliphatic amines including N,N-dimethylamine generally lack a skin sensitizing potential. The N-atom of substances bears a free electron pair, i.e. the substances are strong bases. The free bases are corrosive to the skin,and according to REACH (Annexes VII and VIII, section 8.1, column 2) in-vivo skin sensitisation testing is not allowed. Skin protection is required to protect against skin corrosion and irritation, and this will also protect against sensitization in the unlikely case that the substance should possess a weak sensitization potential.
No classification proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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