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Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
8.41 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
other: MAK-value read across from related chemicals
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
16.82 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
other: MAK-value read across from related chemicals

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
8.41 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
other: MAK-value read across from related chemicals
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
16.82 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
other: MAK-value read across from related chemicals

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Most sensitive endpoint:
irritation (respiratory tract)

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
high hazard (no threshold derived)

Additional information - workers

The primary effect of N, N-dimethylamine (DMBA) is local irritation/corrosion at the point of contact, irrespective whether the exposure occurs on the oral, inhalation, or dermal route. The irritation/corrosion property is a common feature of free aliphatic amines, and there are only gradual differences between primary, secondary, or tertiary amines, or chain lengths of the aliphatic residues. The irritating / corrosive property is attributable to the free electron pair of the free amine, and consequently the cation of salts, like for example the hydrochlorides, is much less irritating and the acute toxicity is significantly lower with much higher LD50-values. DNEL values worker Bearing this in mind, a DNEL value for worker inhalation should be derived that protects against irritation. Dermal contact must be avoided by Risk Management Measures (organisational measures and use of appropriate PPE)and, therefore, no DNEL is required. As stated above, N, N-dimethylbutylamine (DMBA) is corrosive to the skin (Cat 1A) and causes severe eye lesions. Contact to the skin and to the eyes must therefore be avoided by technical means and the use of suitable personal protective equipment. Corrosion occurs very rapidly and there is a clear effect-dose relationship, but virtually no relationship to the exposure period at elevated concentrations. The corrosivity does not allow reaching dose levels that cause systemic toxicity on the oral, inhalation, or dermal route. In inhalation experiments, a low dose of DMBA (2 mg/L) caused respiratory irritation what is considered to represent the most sensitive endpoint. This effect is considered to represent a typical effect of caustic substances like primary, secondary and tertiary aliphatic amines including DMBA. The study with DMBA does not allow to derive a DNEL, but national occupational exposure limit values (OEL) exist for several of the other amines which may be read across to DMBA as far as the underlying toxicological principle is comparable. The table below complies MAK-values which have been established for many members of this category in the range from 1 ppm (diethylamine) to 10 ppm (methylamine). Most substances have MAK-values of 2 and 5, the same is the case for the binding AGW-values. Substances that tend to form carcinogenic nitroso compounds were assigned a MAK-value of 1 ppm.   DMBA is not likely to form nitroso compouds and therefore it is considered to be appropriate to propose a long-term OEL of 2 ppm (8.41 mg/m³), and a short-term OEL of 4 ppm (16.82 mg/m³). These values are considered to be protective against local effects and also against any systemic effect.  

Some physico-chemical data, OEL-values, GHS classification of selected primary, secondary, and tertiary Aliphatic Amines.   (GUBDH, 2012-10-29)

 

C1

C2

C3

C4

EDMA

DMBA

Methyl

Ethyl

n-Propyl

Iso-Propyl

n-Butyl-

Iso-Butyl

Tert-Butyl

Ethyl-dimethyl

Dimethyl-butyl

Primary amines

CAS # 

physical state

74-89-5
gas

75-04-7
gas

107-10-8
liquid

75-31-0
liquid

109-73-9
liquid

78-81-9
liquid

75-64-9
liquid

Vapour pressure

3530 hPa (25°C)

1397 hPa (25°C)

330 hPa (20°C

773 hPa (25°C)

99.8 hPa (20°C

188 hPa (25°C)

496 hPa (25°C)

MAK (ppm)
AGW
SCOEL

10 (I-1) D
10
no value

5 (I-2) D
5
5 (RL2000/39/EG)

no MAK
no value
no value

5 (I-2) C
5
no value

2 (I-2) C
no value
no value

2 (I-2) C
no value
no value

no MAK
no value
no value

GHS classification

acut tox 4; STOT SE 3;
Skin irrit 2; eye dam 1

eye irrit2;
STOT SE 3

no data

Eye irrit 2;
STOT SE 3;
Skin irrit 2

Acut tox 4;
skin corr 1A

no data

no data

Secon-dary amines

CAS # 

physical state

24-40-3
gas

109-89-7
liquid

142-84-7

108-18-9

111-92-2

110-96-3

Vapour pressure

2027 hPa (25°C)

316 hPa (25°C)

26.8 hPa 25°C)

106 hPa (25°C)

2.26 hPa (20°C)

9.7 hPa (25°C)

MAK (ppm)
AGW
SCOEL

2 (I-2) D#
2
no value

5 (I-2) D#
5

5 (RL2000/15/EG)

no MAK
no value
no value

no MAK
no value
no value

no MAK
5
no value

no MAK
no value
no value

GHS classification

acute tox 4; STOT SE 3;
Skin irrit 2; eye dam 1

acute tox 4;
skin corr 1A

acute tox 4;
skin corr 1A

acut tox4;
skin corr 1B

acute tox 4

no data

Tertiary amines

CAS # 

physical state

75-50-3
gas

121-44-8
liquid

102-69-2
liquid

102-82-9
liquid

598-56-1
liquid

927-62-8
liquid

Vapour pressure

1887 hPa(20°C)

70 hPa(20°C)

3.5 hPa (20°C)

0.2 hPa (20°C)

500 hPa (20°C)

67 hPa (20°C)

MAK (ppm)
AGW
SCOEL

2 (I-2) C
no value
no value

1 (I-2) D #
1

2 (RL2000/39/EG)

no MAK
no value
no value

no MAK
no value
no value

2 (I-2) D
no value
no value

no value
no value
no value

GHS classification

acute tox. 4
Skin Corr. 1B

Proposed:

acute tox 3; Skin Corr. 1A



Notes:
- data were initially compiled in 2010 (e.g. GHS classification). MAK-/AGW-/SCOEL-values were checked and updated in November 2012 (GESTIS database)
-
# may lead to highly carcinogenic nitroso compounds
- MAK: scientific MAK-value, Germany; non-binding. In brackets: I -2 = irritation and max. allowable short term concentration factor (duration 15 minutes, 4 times per shift)
- AGW: binding national OEL-value, Germany
- SCOEL: Scientific Committee for EL values, European Community

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
4.21 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
other: MAK-value read across from related chemicals
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
high hazard (no threshold derived)

Additional information - General Population

No data derived, considered to be not relevant, as the general public is no target population.