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EC number: 213-156-1 | CAS number: 927-62-8
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8.41 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: MAK-value read across from related chemicals
- Explanation for the modification of the dose descriptor starting point:
Please refer to the field "Additional information - workers", for further information.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 16.82 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: MAK-value read across from related chemicals
- Explanation for the modification of the dose descriptor starting point:
Please refer to the field "Additional information - workers", for further information.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8.41 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: MAK-value read across from related chemicals
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 16.82 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: MAK-value read across from related chemicals
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
The substance is classified for corrosivity.
Please refer to the field "Additional information - workers", for further information.
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
The substance is classified for corrosivity.
Please refer to the field "Additional information - workers", for further information.
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
The primary effect of N, N-dimethylamine (DMBA) is local irritation/corrosion at the point of contact, irrespective whether the exposure occurs on the oral, inhalation, or dermal route. The irritation/corrosion property is a common feature of free aliphatic amines, and there are only gradual differences between primary, secondary, or tertiary amines, or chain lengths of the aliphatic residues. The irritating / corrosive property is attributable to the free electron pair of the free amine, and consequently the cation of salts, like for example the hydrochlorides, is much less irritating and the acute toxicity is significantly lower with much higher LD50-values.DNEL values workerBearing this in mind, a DNEL value for worker inhalation should be derived that protects against irritation. Dermal contact must be avoided byRisk Management Measures (organisational measures and use of appropriate PPE)and, therefore, no DNEL is required.As stated above, N, N-dimethylbutylamine (DMBA) is corrosive to the skin (Cat 1A) and causes severe eye lesions. Contact to the skin and to the eyes must therefore be avoided by technical means and the use of suitable personal protective equipment. Corrosion occurs very rapidly and there is a clear effect-dose relationship, but virtually no relationship to the exposure period at elevated concentrations. The corrosivity does not allow reaching dose levels that cause systemic toxicity on the oral, inhalation, or dermal route.In inhalation experiments, a low dose of DMBA (2 mg/L) caused respiratory irritation what is considered to represent the most sensitive endpoint. This effect is considered to represent a typical effect of caustic substances like primary, secondary and tertiary aliphatic amines including DMBA. The study with DMBA does not allow to derive a DNEL, but national occupational exposure limit values (OEL) exist for several of the other amines which may be read across to DMBA as far as the underlying toxicological principle is comparable. The table below complies MAK-values which have been established for many members of this category in the range from 1 ppm (diethylamine) to 10 ppm (methylamine). Most substances have MAK-values of 2 and 5, the same is the case for the binding AGW-values. Substances that tend to form carcinogenic nitroso compounds were assigned a MAK-value of 1 ppm. DMBA is not likely to form nitroso compouds and therefore it is considered to be appropriate to propose a long-term OEL of 2 ppm (8.41 mg/m³), and a short-term OEL of 4 ppm (16.82 mg/m³). These values are considered to be protective against local effects and also against any systemic effect.
Some physico-chemical data, OEL-values, GHS classification of selected primary, secondary, and tertiary Aliphatic Amines. (GUBDH, 2012-10-29)
C1 |
C2 |
C3 |
C4 |
EDMA |
DMBA |
||||||||||
Methyl |
Ethyl |
n-Propyl |
Iso-Propyl |
n-Butyl- |
Iso-Butyl |
Tert-Butyl |
Ethyl-dimethyl |
Dimethyl-butyl |
|||||||
Primary amines |
CAS # |
74-89-5 |
75-04-7 |
107-10-8 |
75-31-0 |
109-73-9 |
78-81-9 |
75-64-9 |
|||||||
Vapour pressure |
3530 hPa (25°C) |
1397 hPa (25°C) |
330 hPa (20°C |
773 hPa (25°C) |
99.8 hPa (20°C |
188 hPa (25°C) |
496 hPa (25°C) |
||||||||
MAK (ppm) |
10 (I-1) D |
5 (I-2) D |
no MAK |
5 (I-2) C |
2 (I-2) C |
2 (I-2) C |
no MAK |
||||||||
GHS classification |
acut tox 4; STOT SE 3; |
eye irrit2; |
no data |
Eye irrit 2; |
Acut tox 4; |
no data |
no data |
||||||||
Secon-dary amines |
CAS # |
24-40-3 |
109-89-7 |
142-84-7 |
108-18-9 |
111-92-2 |
110-96-3 |
||||||||
Vapour pressure |
2027 hPa (25°C) |
316 hPa (25°C) |
26.8 hPa 25°C) |
106 hPa (25°C) |
2.26 hPa (20°C) |
9.7 hPa (25°C) |
|||||||||
MAK (ppm) |
2 (I-2) D# |
5 (I-2) D# 5 (RL2000/15/EG) |
no MAK |
no MAK |
no MAK |
no MAK |
|||||||||
GHS classification |
acute tox 4; STOT SE 3; |
acute tox 4; |
acute tox 4; |
acut tox4; |
acute tox 4 |
no data |
|||||||||
Tertiary amines |
CAS # |
75-50-3 |
121-44-8 |
102-69-2 |
102-82-9 |
598-56-1 |
927-62-8 |
||||||||
Vapour pressure |
1887 hPa(20°C) |
70 hPa(20°C) |
3.5 hPa (20°C) |
0.2 hPa (20°C) |
500 hPa (20°C) |
67 hPa (20°C) |
|||||||||
MAK (ppm) |
2 (I-2) C |
1 (I-2) D # 2 (RL2000/39/EG) |
no MAK |
no MAK |
2 (I-2) D |
no value |
|||||||||
GHS classification |
acute tox. 4 |
Proposed: acute tox 3; Skin Corr. 1A |
|||||||||||||
Notes:
- data were initially compiled in 2010 (e.g. GHS classification). MAK-/AGW-/SCOEL-values were checked and updated in November 2012 (GESTIS database)
-#may lead to highly carcinogenic nitroso compounds
- MAK: scientific MAK-value, Germany; non-binding. In brackets: I -2 = irritation and max. allowable short term concentration factor (duration 15 minutes, 4 times per shift)
- AGW: binding national OEL-value, Germany
- SCOEL: Scientific Committee for EL values, European Community
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
No data derived, considered to be not relevant, as the general public is no target population.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
No data derived, considered to be not relevant, as the general public is no target population.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.21 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: MAK-value read across from related chemicals
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
No data derived, considered to be not relevant, as the general public is no target population.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
No data derived, considered to be not relevant, as the general public is no target population.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
No data derived, considered to be not relevant, as the general public is no target population.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
No data derived, considered to be not relevant, as the general public is no target population.
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
No data derived, considered to be not relevant, as the general public is no target population.
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