Registration Dossier
Registration Dossier
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EC number: 947-288-2 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- (Q)SAR method with established scientific validity. The substance falls within the applicability domain of the model.
- Justification for type of information:
- QSAR prediction
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- See attached QPRF.
- GLP compliance:
- no
- Remarks:
- (not relevant)
- Details on sampling:
- Not applicable
- Details on test solutions:
- Not applicable
- Details on test organisms:
- None
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 730.075 mg/L
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR (Baseline toxicity)
- Details on results:
- Validity of model:
1. Defined Endpoint: short term toxicity to aquatic invertebrates (Daphnid).
2. Unambigous algorithm: Linear regression QSAR; Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848
To convert the LC50 from mmol/L to mg/L, multiply by the molecular weight.
3. Applicability domain: applicable to chemicals with log Kow less than 5 and molecular weight less than 1000 g/mol. The model can be suitable for chemicals class of neutral organic.
4. Statistical characteristics: N = 98+31 and the coefficient of determination R² = 0.7704
5. Mechanistic interpretation: related to the partitioning of the substance from water into the organisms lipid phase.
Adequacy of prediction: the substance falls within the applicability domain described above and therefore the predicted value can be considered reliable. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- N = 98+31 and the coefficient of determination R² = 0.7704
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance was predicted to have a 48h-LC50 of 730.075 mg/L to daphnid after 48h of exposure, considering it acts as a non-polar narcotic compound.
- Executive summary:
The short term toxicity to daphnid was estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
The predicted 48h-LC50 was 730.075 mg/L (neutral organic SAR, baseline toxicity). This value was calculated from an estimated log Kow value (1.874) and the following linear regression:
Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848.
The substance falls within the applicability domain of the model and can therefore be considered as a reliable prediction for acute toxicity (48h-LC50) to daphnids considering it acts as a non-polar narcotic compound (MOA 1). Therefore, this endpoint value can be considered valid for sole use within a calculation method in order to determine toxicity of UVCB substances.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- (Q)SAR method with established scientific validity. The substance falls within the applicability domain of the model.
- Justification for type of information:
- QSAR prediction
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- See attached QPRF.
- GLP compliance:
- no
- Remarks:
- (not relevant)
- Details on sampling:
- Not applicable
- Details on test solutions:
- Not applicable
- Details on test organisms:
- None
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.762 mg/L
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR (Baseline toxicity)
- Details on results:
- Validity of model:
1. Defined Endpoint: short term toxicity to aquatic invertebrates (Daphnid).
2. Unambigous algorithm: Linear regression QSAR; Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848
To convert the LC50 from mmol/L to mg/L, multiply by the molecular weight.
3. Applicability domain: applicable to chemicals with log Kow less than 5 and molecular weight less than 1000 g/mol. The model can be suitable for chemicals class of neutral organic.
4. Statistical characteristics: N = 98+31 and the coefficient of determination R² = 0.7704
5. Mechanistic interpretation: related to the partitioning of the substance from water into the organisms lipid phase.
Adequacy of prediction: the substance falls within the applicability domain described above and therefore the predicted value can be considered reliable. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- N = 98+31 and the coefficient of determination R² = 0.7704
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance was predicted to have a 48h-LC50 of 4.762 mg/L to daphnid after 48h of exposure, considering it acts as a non-polar narcotic compound.
- Executive summary:
The short term toxicity to daphnid was estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
The predicted 48h-LC50 was 4.762 mg/L (neutral organic SAR, baseline toxicity). This value was calculated from an estimated log Kow value (3.536) and the following linear regression:
Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848.
The substance falls within the applicability domain of the model and can therefore be considered as a reliable prediction for acute toxicity (48h-LC50) to daphnids considering it acts as a non-polar narcotic compound (MOA 1). Therefore, this endpoint value can be considered valid for sole use within a calculation method in order to determine toxicity of UVCB substances.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- (Q)SAR method with established scientific validity. The substance falls within the applicability domain of the model.
- Justification for type of information:
- QSAR prediction
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- See attached QPRF.
- GLP compliance:
- no
- Remarks:
- (not relevant)
- Details on sampling:
- Not applicable
- Details on test solutions:
- Not applicable
- Details on test organisms:
- None
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.881 mg/L
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR (Baseline toxicity)
- Details on results:
- Validity of model:
1. Defined Endpoint: short term toxicity to aquatic invertebrates (Daphnid).
2. Unambigous algorithm: Linear regression QSAR; Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848
To convert the LC50 from mmol/L to mg/L, multiply by the molecular weight.
3. Applicability domain: applicable to chemicals with log Kow less than 5 and molecular weight less than 1000 g/mol. The model can be suitable for chemicals class of neutral organic.
4. Statistical characteristics: N = 98+31 and the coefficient of determination R² = 0.7704
5. Mechanistic interpretation: related to the partitioning of the substance from water into the organisms lipid phase.
Adequacy of prediction: the substance falls within the applicability domain described above and therefore the predicted value can be considered reliable. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- N = 98+31 and the coefficient of determination R² = 0.7704
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance was predicted to have a 48h-LC50 of 1.881 mg/L to daphnid after 48h of exposure, considering it acts as a non-polar narcotic compound.
- Executive summary:
The short term toxicity to daphnid was estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
The predicted 48h-LC50 was 1.881 mg/L (neutral organic SAR, baseline toxicity). This value was calculated from an estimated log Kow value (4.065) and the following linear regression:
Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848.
The substance falls within the applicability domain of the model and can therefore be considered as a reliable prediction for acute toxicity (48h-LC50) to daphnids considering it acts as a non-polar narcotic compound (MoA 1). Therefore, this endpoint value can be considered valid for sole use within a calculation method in order to determine toxicity of UVCB substances.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- See attached QPRF.
- GLP compliance:
- no
- Remarks:
- (not relevant)
- Details on sampling:
- Not applicable
- Details on test solutions:
- Not applicable
- Details on test organisms:
- None
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- other: No Effect at Saturation
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR (Baseline toxicity)
- Details on results:
- Validity of model:
1. Defined Endpoint: short term toxicity to aquatic invertebrates (Daphnid).
2. Unambigous algorithm: Linear regression QSAR; Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848
To convert the LC50 from mmol/L to mg/L, multiply by the molecular weight.
3. Applicability domain: applicable to chemicals with log Kow less than 5 and molecular weight less than 1000 g/mol. The model can be suitable for chemicals class of neutral organic.
4. Statistical characteristics: N = 98+31 and the coefficient of determination R² = 0.7704
5. Mechanistic interpretation: related to the partitioning of the substance from water into the organisms lipid phase.
Adequacy of prediction: the substance has a predicted log kow of 5.678 (Kowwin v1.68 estimate). According to ECOSAR v1.11, if the log kow of a chemical belonging to the class of neutral organics is greater than 5.0 for daphnid LC50 predictions (specific cut-off), then no effect at saturation (NES) is expected for this endpoint. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- N = 98+31 and the coefficient of determination R² = 0.7704
- Conclusions:
- No effect at saturation is expected for this coumpound after 48h of exposure.
- Executive summary:
The short term toxicity to daphnid of the substance was estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
According to ECOSAR v1.11, if the log kow of a chemical belonging to the class of neutral organics is greater than 5.0 for daphnid LC50 predictions (specific cut-off), then no effect at saturation (NES) is expected for this endpoint. The substance has a predicted log kow of 5.678 (Kowwin v1.68 estimate).
Therefore, no effect at saturation is expected for this compound after 48h of exposure.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- (Q)SAR method with established scientific validity. The substance falls within the applicability domain of the model.
- Justification for type of information:
- QSAR prediction
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- See attached QPRF.
- GLP compliance:
- no
- Remarks:
- (not relevant)
- Details on sampling:
- Not applicable
- Details on test solutions:
- Not applicable
- Details on test organisms:
- None
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 601.005 mg/L
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR (Baseline toxicity)
- Details on results:
- Validity of model:
1. Defined Endpoint: short term toxicity to aquatic invertebrates (Daphnid).
2. Unambigous algorithm: Linear regression QSAR; Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848
To convert the LC50 from mmol/L to mg/L, multiply by the molecular weight.
3. Applicability domain: applicable to chemicals with log Kow less than 5 and molecular weight less than 1000 g/mol. The model can be suitable for chemicals class of neutral organic.
4. Statistical characteristics: N = 98+31 and the coefficient of determination R² = 0.7704
5. Mechanistic interpretation: related to the partitioning of the substance from water into the organisms lipid phase.
Adequacy of prediction: the substance falls within the applicability domain described above and therefore the predicted value can be considered reliable. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- N = 98+31 and the coefficient of determination R² = 0.7704
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance was predicted to have a 48h-LC50 of 601.005 mg/L to daphnid after 48h of exposure, considering it acts as a non-polar narcotic compound.
It should be noted that the water solubility of the substance reported in ECOSAR v1.11 is 570 mg/L (exp value). Therefore, the chemical may not be soluble enough to measure the predicted effect. - Executive summary:
The short term toxicity to daphnid was estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
The predicted 48h-LC50 was 601.005 mg/L (neutral organic SAR, baseline toxicity). This value was calculated from an estimated log Kow value (2.071) and the following linear regression:
Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848.
The substance falls within the applicability domain of the model and can therefore be considered as a reliable prediction for acute toxicity (48h-LC50) to daphnids considering it acts as a non-polar narcotic compound (MOA 1). Therefore, this endpoint value can be considered valid for sole use within a calculation method in order to determine toxicity of UVCB substances.
Moreover, it should be noted that the water solubility of the substance reported in ECOSAR v1.11 is 570 mg/L (exp value). Therefore, the chemical may not be soluble enough to measure the predicted effect.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- (Q)SAR method with established scientific validity. The substance falls within the applicability domain of the model.
- Justification for type of information:
- QSAR prediction
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- See attached QPRF.
- GLP compliance:
- no
- Remarks:
- (not relevant)
- Details on sampling:
- Not applicable
- Details on test solutions:
- Not applicable
- Details on test organisms:
- None
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 459.167 mg/L
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR (Baseline toxicity)
- Details on results:
- Validity of model:
1. Defined Endpoint: short term toxicity to aquatic invertebrates (Daphnid).
2. Unambigous algorithm: Linear regression QSAR; Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848
To convert the LC50 from mmol/L to mg/L, multiply by the molecular weight.
3. Applicability domain: applicable to chemicals with log Kow less than 5 and molecular weight less than 1000 g/mol. The model can be suitable for chemicals class of neutral organic.
4. Statistical characteristics: N = 98+31 and the coefficient of determination R² = 0.7704
5. Mechanistic interpretation: related to the partitioning of the substance from water into the organisms lipid phase.
Adequacy of prediction: the substance falls within the applicability domain described above and therefore the predicted value can be considered reliable. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- N = 98+31 and the coefficient of determination R² = 0.7704
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance was predicted to have a 48h-LC50 of 459.167 mg/L to daphnid after 48h of exposure, considering it acts as a non-polar narcotic compound.
- Executive summary:
The short term toxicity to daphnid was estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
The predicted 48h-LC50 was 459.167 mg/L (neutral organic SAR, baseline toxicity). This value was calculated from an estimated log Kow value (1.055) and the following linear regression:
Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848.
The substance falls within the applicability domain of the model and can therefore be considered as a reliable prediction for acute toxicity (48h-LC50) to daphnids considering it acts as a non-polar narcotic compound (MOA 1). Therefore, this endpoint value can be considered valid for sole use within a calculation method in order to determine toxicity of UVCB substances.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- (Q)SAR method with established scientific validity. The substance falls within the applicability domain of the model.
- Justification for type of information:
- QSAR prediction
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- See attached QPRF.
- GLP compliance:
- no
- Remarks:
- (not relevant)
- Details on sampling:
- Not applicable
- Details on test solutions:
- Not applicable
- Details on test organisms:
- None
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 313.337 mg/L
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR (Baseline toxicity)
- Details on results:
- Validity of model:
1. Defined Endpoint: short term toxicity to aquatic invertebrates (Daphnid).
2. Unambigous algorithm: Linear regression QSAR; Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848
To convert the LC50 from mmol/L to mg/L, multiply by the molecular weight.
3. Applicability domain: applicable to chemicals with log Kow less than 5 and molecular weight less than 1000 g/mol. The model can be suitable for chemicals class of neutral organic.
4. Statistical characteristics: N = 98+31 and the coefficient of determination R² = 0.7704
5. Mechanistic interpretation: related to the partitioning of the substance from water into the organisms lipid phase.
Adequacy of prediction: the substance falls within the applicability domain described above and therefore the predicted value can be considered reliable. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- N = 98+31 and the coefficient of determination R² = 0.7704
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance was predicted to have a 48h-LC50 of 313.337 mg/L to daphnid after 48h of exposure, considering it acts as a non-polar narcotic compound.
- Executive summary:
The short term toxicity to daphnid was estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
The predicted 48h-LC50 was 313.337 mg/L (neutral organic SAR, baseline toxicity). This value was calculated from an estimated log Kow value (1.076) and the following linear regression:
Log 48h-LC50 (mmol/L) = -0.858 (log Kow) + 1.3848.
The substance falls within the applicability domain of the model and can therefore be considered as a reliable prediction for acute toxicity (48h-LC50) to daphnids considering it acts as a non-polar narcotic compound (MoA 1). Therefore, this endpoint value can be considered valid for sole use within a calculation method in order to determine toxicity of UVCB substances.
Referenceopen allclose all
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Description of key information
Constituent approach, additivity formula:
48h-EC50 for aquatic invertebrates = 3.32 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.32 mg/L
Additional information
Since the registered substance is a NCS with a well-defined composition, its acute toxicity to aquatic invertebrates can be estimated using adequate toxicity data of major constituents. For that endpoint, the estimation of the toxicity of the mixture was based on the individual toxicities of each major constituent using typical percentages of these compounds. Seven constituents were taken into account for this assessment, representing 98.23% of the mixture. The toxicity of these constituents has been predicted using ECOSAR v1.11 from EPISUITE tool, considering they act as non-polar narcotic compounds (neutral organic SAR, baseline toxicity). These data are summarized in the table 2 of the document attached in section 13.2: "data on constituents for e-fate and ecotox endpoints".
Then, the acute toxicity of the susbtance to aquatic invertebrates was estimated using the following additivity formula, as recommended in the Regulation (EC) No 1272/2008 (CLP):
∑ Ci / L(E)C50m = ∑ (Ci / L(E)C50i)
Where,
Ci = concentration of component i (weight percentage);
L(E)C50i = LC50 or EC50 for component i, in mg/L;
L(E)C50m = L(E)C50 of the part of the mixture with test data;
The 48h-LC50m value for the substance was estimated to be 3.32 mg/L for aquatic invertebrates for a typical mixture.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
