Registration Dossier
Registration Dossier
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EC number: 946-353-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The analogue substace was tested for sensitising properties following EU Method B6, GPMT (NONS dossier, 1988).
Guinea Pig were topycally and intradermally induced and then challenged at a concentration of the topic exposure at 10% of the test substance. Under the experimental conditions at the 10% dose the results at challenge time is 0% of skin positive reactions.
Based on the read across considerations the same resutls apply to Reactive Orange 12:1.
Migrated from Short description of key information:
GPMT, 10% epicutaneous, not skin sensitizing
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
A substance is classified as skin sensitizer cat 2 for Guine Pig Maximisation test
when >0.1 to <1% intradermal induction the positive skin reactions are>30 to <60% or
at >1% intradermal, the positive skin reactions are >30%
Based on the results of the GPMT the substance is not classified as skin sensitizer.
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