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EC number: 279-348-2 | CAS number: 79915-74-5
The acute oral toxicity of Isopropoxyethyl salicylate was examined according to OECD guideline 423 and GLP principles in Sprague-Dawley rats (3 females per dose step). All animals died at 2000 mg/kg bw, however, no deaths occurred at 300 mg/kg bw. All animals exposed to 2000 mg/kg died 6 hours after administration or on day 1 after administration. The animals that died on day 1 after administration showed decreased spontaneous movement and reddish urine at 6 hours after administration. All animals in the 300 mg/kg bw showed reddish urine starting 6 hours after administration, but this effect disappeared by day 2 after administration and there were no abnormalities thereafter. At 300 mg/kg bw, body weight increase was slightly low on day 1 after administration and suppressed body weight gain was observed, but body weight increase was normal thereafter. There were no abnormalities in the results of necropsy of the animals that died or that survived. On the basis of the results described above, it was estimated that the oral LD50 value of Isopropoxyethyl salicylate was higher than 300 mg/kg but lower than 2000 mg/kg bw.
Based on these data, the LD50 for Isopropoxyethyl salicylate was determined to be between 300 and 2000 mg/kg bw, the substance is classified for oral toxicity in category 4 according to Regulation (EC) 1272/2008.
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