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Physical & Chemical properties

Partition coefficient

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Administrative data

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June 27, 2017 - December 11, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
estimation method (solubility ratio)
Specific details on test material used for the study:
- Analytical purity: 100% (UVCB)
- Purity test date: 06 June 2017
- Lot/batch No.: 180517GT41
- Expiration date of the lot/batch: 31 December 2017
- Appearance: Beige pasty solid
- Storage: At room temperature
Key result
Type:
log Pow
Partition coefficient:
0.8
Temp.:
20 °C
Remarks on result:
other: estimation method

The n-octanol solubility of the test item at 20.0 ± 0.2°C was estimated to be 276 mg/L. The critical micelle concentration at 20.0 ± 0.2°C was estimated to be 39.9 mg/L. This results in a Pow of 6.9 corresponding with a log Pow of 0.8.

Conclusions:
The partition coefficient of the test material calculated using the n-octanol solubility and the critical micelle concentration is 6.9 (log Pow = 0.8).
Executive summary:

The n-octanol/water partition coefficient Pow of the test item was determined in a GLP-compliant study performed in accordance with EU Method A.8 and OECD Guidelines No. 107/117, using the estimation method. The partition coefficient of the test material calculated using the n-octanol solubility and the critical micelle concentration is 6.9 (log Pow = 0.8).

Description of key information

The n-octanol/water partition coefficient Pow of the test item was determined in a GLP-compliant study performed in accordance with EU Method A.8 and OECD Guidelines No. 107/117, using the estimation method. The partition coefficient of the test material calculated using the n-octanol solubility and the critical micelle concentration is 6.9 (log Pow = 0.8).

Key value for chemical safety assessment

Log Kow (Log Pow):
0.8
at the temperature of:
20 °C

Additional information

The n-octanol/water partition coefficient log Pow of the test item was determined in one GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.