D-tetramethrin

GHS

General Information

Name:

D-Tetramethrin

Implementation:

EU

Type of classification:

harmonised classification

Remarks:

Although d-Tetramethrin (CAS nr. 548460-64-6) is not specifically subject to harmonized classification according to the 13th ATP of CLP (COMMISSION REGULATION (EU) 2018/1480), Tetramethrin (CAS nr. 7696-12-0) is listed in the ATP, hence it is considered appropriate reading-across the same classification to d-Tetramethrin.

In acute toxicity studies by oral, dermal, and inhalation exposure, no mortality was seen at 2000 mg/kg bw, 2000 mg/kg bw, and 5.63 mg/L, respectively. Thus, the substance does not require classification for acute toxicity according to CLP (Regulation EC No. 1272/2008).

However, with a Decision adopted on 16 September 2016, RAC concluded that Tetramethrin should be classified as Acute Toxicity Category 4, via oral route (H302: Harmful if swallowed) based on a study on d-trans-tetramethrin in mices.

In addition RAC agreed on classification as STOT SE 2 (H371; by inhalation route) on the basis of evidence from studies on d-trans-tetramethrin and Tetramethrin in experimental animals at a moderate concentration. The observed neurotoxic effects were essentially acute effects. The same classification as Acute Toxicity Category 4, via oral route (H302: Harmful if swallowed) and STOT SE 2 (H371; by inhalation route)

is applied to d-Tetramethrin.

No data on carcinogenicity are available for d-Tetramethrin (CAS nr.548460-64-6) at Endura as this is not a data requirement for the current registration tonnage band (10 -100 t/y)

According to the RAC opinion, Tetramethin has been classified for carcinogenicity Category 2 (H351: Suspected of causing cancer) based on two independent rat studies not available at Endura, demonstrating a statistically significant increase in the incidence of Leydig cell tumors in male rats. The same classification for carcinogenicity Category 2 (H351: Suspected of causing cancer) is attributed to d-Tetramethrin.

Based on the lowest acute toxicity observed in a study not available at Endura, Tetramethrin is classified as: Aquatic Acute 1 (H400) with an acute M-factor of 100, Aquatic Chronic 1 (H410) with a chronic M-factor of 100.

According to RAC Decision adopted on 16 September 2016, based on the lowest acute toxicity observed in a study not available at Endura, Tetramethrin is classified as: Aquatic Acute 1 (H400) with an acute M-factor of 100, Aquatic Chronic 1 (H410) with a chronic M-factor of 100.

Although d-Tetramethrin (CAS nr.548460-64-6) is not specifically discussed in the RAC Decision adopted on 16 September 2016, it is considered appropriate reading-acrossthe same M-factors to d-Tetramethrin.

Related composition

Related composition:

D-Tetramethrin

D-Tetramethrin

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data lacking

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data lacking

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data lacking

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data conclusive but not sufficient for classification

Desensitized explosives

Reason for no classification:

data conclusive but not sufficient for classification

Health hazards

Acute toxicity - oral

Hazard category:

Acute Tox. 4

Hazard statement:

H302: Harmful if swallowed.

Acute toxicity - dermal

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - inhalation

Reason for no classification:

data conclusive but not sufficient for classification

Skin corrosion / irritation

Reason for no classification:

data conclusive but not sufficient for classification

Serious eye damage / eye irritation

Reason for no classification:

data conclusive but not sufficient for classification

Respiratory sensitisation

Reason for no classification:

data lacking

Skin sensitisation

Reason for no classification:

data conclusive but not sufficient for classification

Aspiration hazard

Reason for no classification:

data conclusive but not sufficient for classification

Reproductive toxicity

Reason for no classification:

data conclusive but not sufficient for classification

Effects on or via lactation

Reason for no classification:

data lacking

Germ cell mutagenicity

Reason for no classification:

data conclusive but not sufficient for classification

Carcinogenicity

Hazard category:

Carc. 2

Hazard statement:

H351: Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routs of exposure cause the hazard>.

1. Specific target organ toxicity - single (STOT-SE)

Hazard category:

STOT Single Exp. 2

Hazard statement:

H371: May cause damage to organs <or state all organs affected, if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Affected organs:

other: nervous system

Route of exposure:

inhalation

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data conclusive but not sufficient for classification

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Hazard category:

Aquatic Acute 1

Hazard statement:

H400: Very toxic to aquatic life.

Hazardous to the aquatic environment (long-term)

Hazard category:

Aquatic Chronic 1

Hazard statement:

H410: Very toxic to aquatic life with long lasting effects.

M-Factor acute:

100

M-Factor chronic:

100

Hazardous to the ozone layer

Reason for no classification:

data conclusive but not sufficient for classification

Labelling

Signal word:

Warning

Hazard pictogram

GHS07: exclamation mark

GHS08: health hazard

GHS09: environment

Hazard statements

H351: Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routs of exposure cause the hazard>.

H302: Harmful if swallowed.

H371: May cause damage to organs <or state all organs affected, if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

H410: Very toxic to aquatic life with long lasting effects.

Precautionary statements

P273: Avoid release to the environment.

P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P301+P312: IF SWALLOWED: Call a POISON CENTER/doctor/... if you feel unwell.

P260: Do not breathe dust/fume/gas/mist/vapours/spray.