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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1983

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
Version / remarks:
Details of the methodology are not given in the review. Test was for 90 days on rats
Deviations:
not specified
Principles of method if other than guideline:
Benzophenone-1, fed to 40 rats at doses of 0, 0.19, 0.6, 1.9 g/kg for 90 days. Exact details are no given in the report.
GLP compliance:
not specified
Remarks:
Data produced prior to GLP requiements being required.

Test material

Constituent 1
Reference substance name:
2,4-dihydroxybenzophenone
EC Number:
205-029-4
EC Name:
2,4-dihydroxybenzophenone
Cas Number:
131-56-6
Molecular formula:
C13H10O3
IUPAC Name:
2,4-dihydroxybenzophenone

Test animals

Species:
rat
Strain:
other: Albino
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
90 days
Frequency of treatment:
Daily

Examinations

Sacrifice and pathology:
Depressed growth, liver and kidney lesions at 0.6 and 1.9 g/kg

Results and discussion

Results of examinations

Mortality:
no mortality observed

Effect levels

Dose descriptor:
NOEL
Effect level:
0.19 other: g/kg
Based on:
test mat.
Sex:
not specified
Basis for effect level:
body weight and weight gain
clinical signs

Target system / organ toxicity

Critical effects observed:
yes
Lowest effective dose / conc.:
0.6 other: g/kg
System:
urinary
Organ:
kidney
liver
Treatment related:
not specified

Applicant's summary and conclusion

Conclusions:
Benzophenone-1, fed to 40 rats at doses of 0 - l .9 g/kg for 90 days, produced depressed growth and liver and kidney lesions in animals at doses of 0.6 and 1.9 g/kg.