Registration Dossier
Registration Dossier
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EC number: 231-453-4 | CAS number: 7560-83-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficient information to take into account for evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Die Untersuchungen des Verhaltens von Cyclohexylamin (CHA) und Dicyclohexylamin (DCHA) im Koerper.
- Author:
- Filov VA
- Year:
- 1 968
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 7, 29-33.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other:
- Principles of method if other than guideline:
- 2 ml rat liver homogenate was mixed with 8 ml physiologic solution containing 0.04 mg/ml for 1 hr.
Rabbit liver slice (8 cm²) was exposed to 20 ml physiologic solution containing 0.08 mg/ml for up to 18 hrs - GLP compliance:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- IUPAC Name:
- N-cyclohexylcyclohexanamine
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: rat, rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 18h
- Doses:
- 20 ml physiologic solution containing 0.08 mg/ml
- No. of animals per group:
- No data
- Control animals:
- no
Results and discussion
Any other information on results incl. tables
No change in the concentration of dicyclohexylamine detected.
Applicant's summary and conclusion
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