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EC number: 456-900-2 | CAS number: 51285-81-5 GADOLINIUMSULFIT-TRIHYDRAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 April 2003 - 8 October 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Gadoliniumsulfite trihydrate
- EC Number:
- 456-900-2
- EC Name:
- Gadoliniumsulfite trihydrate
- Cas Number:
- 51285-81-5
- Molecular formula:
- Gd2(SO3)3*3H2O
- IUPAC Name:
- digadolinium(3+) trihydrate trisulfite
- Test material form:
- solid: particulate/powder
- Details on test material:
- Off white, crystalline powder
Batch number FSG 3896 or 02-FW-095
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- The quantification of the test material was performed using ICP-OES.
Test solutions
- Details on test solutions:
- The testmedium (reconstituted water and test material) was freshly prepared. Therefore, the calibrated flask with test material and vehicle, reconstituted water, was treated in an ultrasonic device for 1 hour. Subsequently, the preparation was stirred with a magnetic stirrer for further 23 hours. After that the formulation was given through a nutsch filter (pore size >10- <16 µm). The filtrate was used for the study.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- The fish were acclimatized to the conditions of the laboratory for more than 14 days and were held in the reconstituted water at least for 7 days before testing. During the acclimatization, until one day before the experimental part, the fish were fed a JBL Novo Bel diet (JBL GmbH & Co. KG, Neuhofen). During the week before testing, the mortality ofthe fish batch was lowerthan 5%. At the start of the test, 1 0 fish per group were introduced in a random order into each aquarium filled with test medium or reconstituted water.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- The test material solution was renewed after each 24 hours.
Test conditions
- Hardness:
- CaCl2 · 2H2O --> 294 mg/L
MgS04 · 7H2O --> 123 mg/L
NaHCO3 --> 65 mg/L
KCI --> 5.8 mg/L - Test temperature:
- 23 to 24 °C
- pH:
- 7.4 to 7.8
- Dissolved oxygen:
- 68.0 to 95.0 %
- Nominal and measured concentrations:
- nominal concentration: 100 mg/L
measured concentration: 1.03 mg/L (solubility in water) - Details on test conditions:
- The Brachydanio rerio were kept in closed all-glass aquaria. The study was located in an air-conditioned room in the Institute of Toxicology. Lighting was controlled by a timer to provide a 12 hours light - 12 hours dark regime. The Brachydanio rerio were not fed during the study. Before the experimental part the reconstituted water was freshly prepared. After preparation the reconstituted water was aerated for 24 hours.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1.03 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1.03 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1.03 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1.03 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 1.03 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- other: Highest concentration tested. no mortality was observed.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- An aqueous solution of a nominal concentration of 100 mg/L with Gadoliniumsulfite trihydrate revealed no aquatic toxicity in this test system. The 96 hours LC50 value to Brachydanio rerio exceeded the mean maximal solubility (1.03 mg/L analytically) of the test material in reconstituted water and, thus, could not be determined in this test.
- Executive summary:
The objective of this study was to determine the acute toxicity of the Gadoliniumsulfite trihydrate using Brachydanio rerio. Forthis purpose, 10 fishin a testmaterial group and further 10 fish in a control group were exposed over 96 hours, under defined conditions in a Iimit-test. The fish were observed for signs of toxicity or death. Brachydanio rerio were exposed to a test material concentration of nominal 1 00 mg/L (Iimit-test) in a closed semistatic test system. The test material solution was renewed after each 24, hours. Analytical controls were carried out from each of the freshly prepared test media and after 24 hours. A calculation with the 8 values revealed a mean "analytical" test material concentration of ab out 1 % of the nominal concentration. Brachydanio rerio exposed to an aqueous solution of nominal 100 mg Gadoliniumsulfite trihydrate per Iiter (mean maximal solubility of 1.03 mg/L) were not affected. For the Gadoliniumsulfite trihydrate the following LC50 values and no effect concentration
for Brachydanio rerio were determined:
Nominal Analytical
24 h LC50 >100 mg/L > 1.03 mg/L
48 h LC50 >100 mg/L > 1.03 mg/L
72 h LC50 >100 mg/L > 1.03 mg/L
96 h LC50 >100 mg/L > 1.03 mg/L
NOEC >100 mg/L > 1.03 mg/L
An aqueous solution of a nominal concentration of 100 mg/L with Gadoliniumsulfite trihydrate revealed no aquatic toxicity in this test system. The 96 hours LC50 value to Brachydanio rerio exceeded the mean maximal solubility (1.03 mg/L analytically) of the test material in reconstituted water and, thus, could not be determined in this test.
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