Registration Dossier
Registration Dossier
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EC number: 284-723-9 | CAS number: 84962-27-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Test atmosphere generation not adequately described. Design in principle designed for vapours.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- 8h-exposure of rats to a test atmosphere generated by blowing air through a layer of the test substance, 7-day post-treatment observation period
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, hydrogen bis[3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-2-hydroxy-5-nitrobenzenesulfonato(3-)]chromate(3-), compd. with 3-[(2-ethylhexyl)oxy]-1-propanamine
- EC Number:
- 284-723-9
- EC Name:
- Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, hydrogen bis[3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-2-hydroxy-5-nitrobenzenesulfonato(3-)]chromate(3-), compd. with 3-[(2-ethylhexyl)oxy]-1-propanamine
- Cas Number:
- 84962-27-6
- Molecular formula:
- C32H20CrN10O14S2.1.5(C28H31N2O3).1.5(C11H25NO)
- IUPAC Name:
- Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, hydrogen bis[3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-2- hydroxy-5-nitrobenzenesulfonato(3-)]chromate(3-), compd. with 3-[(2-ethylhexyl)oxy]-1-propanamine
- Details on test material:
- Name of the test substance used in the study report: Neozaponechtfeuerrot BL (96-3058)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h - Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- The nominal concentration could be usuallycalculated as quotient of the amount of test substance weight loss during the exposure, which is given in the raw data, and the amount of air used during the exposure.
- Duration of exposure:
- 8 h
- Concentrations:
- Mean concentration: 1.36 mg/l
- No. of animals per sex per dose:
- 12
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: prior to and at the end of study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 1.36 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: dust
- Mortality:
- None
- Clinical signs:
- other: Slight mucosal irritations, reddish-coloured fur
- Gross pathology:
- Nothing abnormal detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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