Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
other: Expert assessment
Adequacy of study:
key study
Study period:
October 04, 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An assessment was undertaken based on literature data on the substance and on structural analogues.

Data source

Reference
Reference Type:
other: Expert assessment
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
An assessment was undertaken based on literature data on the substance and on structural analogues.

Test material

Constituent 1
Chemical structure
Reference substance name:
1-[(2-hydroxyethyl)thio]propan-2-ol
EC Number:
229-765-0
EC Name:
1-[(2-hydroxyethyl)thio]propan-2-ol
Cas Number:
6713-03-7
Molecular formula:
C5H12O2S
IUPAC Name:
1-[(2-hydroxyethyl)sulfanyl]propan-2-ol

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

open allclose all
Key result
Dose descriptor:
LOAEL
Effect level:
3 870 other: mg/kg/day
Based on:
test mat.
Sex:
female
Basis for effect level:
body weight and weight gain
food consumption and compound intake
reproductive performance
Remarks on result:
other: An assessment was undertaken based on literature data on the substance and on structural analogues.
Key result
Dose descriptor:
NOAEL
Effect level:
1 290 other: mg/kg/day
Based on:
test mat.
Sex:
female
Basis for effect level:
body weight and weight gain
food consumption and compound intake
reproductive performance
Remarks on result:
other: An assessment was undertaken based on literature data on the substance and on structural analogues.

Target system / organ toxicity (P0)

Critical effects observed:
not specified

Results: P1 (second parental generation)

Effect levels (P1)

Remarks on result:
not measured/tested

Target system / organ toxicity (P1)

Critical effects observed:
no

Results: F1 generation

Effect levels (F1)

Remarks on result:
not measured/tested

Target system / organ toxicity (F1)

Critical effects observed:
no

Results: F2 generation

Effect levels (F2)

Remarks on result:
not measured/tested

Target system / organ toxicity (F2)

Critical effects observed:
no

Overall reproductive toxicity

Key result
Reproductive effects observed:
yes
Lowest effective dose / conc.:
3 870 other: mg/kg/day
Treatment related:
yes
Relation to other toxic effects:
not specified
Dose response relationship:
not specified
Relevant for humans:
not specified

Applicant's summary and conclusion

Conclusions:
An assessment was undertaken based on literature data on the substance and on structural analogues. It was concluded that the substance was not toxic to reproduction.
Executive summary:

 An assessment was undertaken based on literature data on the substance and on structural analogues. It was possible to establish a read-across between the registered substance and an analogue those toxicity to reproduction is expected to represent a worst-case scenario.

From the available data on this analogue it was concluded that that the LOAEL for maternal and developmental toxicity is 3,870 mg/kg/day while the NOAEL is 1,290 mg/kg/day. No additional animal testing is considered necessary for the purpose of assessing the reproductive/developmental toxicity of 1-[(2-hydroxyethyl)thio]propan-2-ol.