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Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute dermal toxicity test was carried out to study the effects of test chemical on rabbits
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology
Reference Type:
other: Authoritative database
Title:
Acute dermal toxicity study - rabbit
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus
Reference Type:
secondary source
Title:
Acute oral toxicity - rabbit
Author:
RTECS
Year:
1997
Bibliographic source:
RTECS

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity test was carried out to study the effects of test chemical on rabbits.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methoxyphenylacetone
EC Number:
204-578-7
EC Name:
4-methoxyphenylacetone
Cas Number:
122-84-9
Molecular formula:
C10H12O2
IUPAC Name:
1-(4-methoxyphenyl)propan-2-one
Details on test material:
- Name of test material (IUPAC name): 1-(4-methoxyphenyl)propan-2-one- Common name: 4-Methoxyphenylacetone- Molecular formula: C10H12O2- Molecular weight: 164.203 g/mol- Smiles notation: c1(ccc(OC)cc1)CC(C)=O- InChl: 1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3- Substance type: Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed in treated rabbits at 5000 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with test chemical by dermal application.
Executive summary:

Acute dermal toxicity study was conducted in rabbits by using test chemical at the concentration of 5000 mg/kg bw by dermal application. No mortality was observed in treated rabbits at dose 5000 mg/kg bw. Therefore, LD50 value was considered to be >5000 mg/kg bw, when rabbits were treated with test chemical by dermal application.