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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (IUPAC name): 2-(2-(4-((4-Ethoxyphenyl)methylamino)phenyl)ethenyl)-1,3,3-trimethyl-3H-indolium- Molecular formula: C28H31N2O.Cl- Molecular weight: 447.019 g/mol- Smiles notation: [N+]1(=C(C(c2ccccc12)(C)C)\C=C\c1ccc(cc1)N(C)c1ccc(cc1)OCC)C.[ClH-]- InChl: 1S/C28H31N2O.ClH/c1-6-31-24-18-16-23(17-19-24)29(4)22-14-11-21(12-15-22)13-20-27-28(2,3)25-9-7-8-10-26(25)30(27)5;/h7-20H,6H2,1-5H3;1H/q+1;/p-1- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
1650 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
Details on study design:- Other examinations performed: clinical signs
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 650 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at dose 1650 mg/kg bw
Clinical signs:
In clinical signs observations,changes in urine composition,behavioral excitement and convulsions or effect on seizure threshold were observed.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 1650 mg/kg bw,when rats were treated with test chemical orally.
Executive summary:

Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose1650 mg/kg bw.In clinical signs observations,changes in urine composition,behavioral excitement and convulsions or effect on seizure threshold were observed.Hence,LD50 value was considered to be1650 mg/kg bw,when rats were treated with test chemical orally.