Registration Dossier
Registration Dossier
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EC number: 947-398-0 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
72h-EL50/EL10 > 100 mg/L (loading, nominal) for growth rate of Pseudokirchnerella subcapitata (OECD 201, read across)
Key value for chemical safety assessment
Additional information
Since no study assessing the toxicity of Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates to aquatic algae is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to source substance Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates, potassium salts (CAS 91744-36-8) was conducted.
This read-across is justified because both, target and source substance, are structurally identical except for the fact that the source substance is the potassium salt of the target substance. The potassium ions are not considered to alter environmental fate and ecotoxicity of the source substance in comparison to the target substance. Thus, functional groups, mode of action, biotransformation, environmental behavior and ecotoxicity profile can with very high certainty assumed to be identical.
The study with the read across substance was performed according to GLP and OECD guideline 201 using Pseudokirchnerella subcapitata as test organism (Vryenhoef 2012). Loading rate WAFs between 6.25 and 100 mg/L were tested over an exposure time of 72h. Exposure of the algae to the test item gave EL50/ EL10 and NOELr values > 100 mg/L loading rate. This indicates that in the range of solubility the test item was not harmful to algae. Based on the structural similarity this is also considered to be true for the target substance Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates.
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