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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-05
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
appearance / physical state / colour
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline followed
Principles of method if other than guideline:
The Appearance/physical state and colour were sourced from the review of melting point test (as determined according to EC Methods A.1 and OECD Test Guidelines 102 (1995)).
GLP compliance:
no
Physical state at 20°C and 1013 hPa:
solid
Remarks:
Based on the test item decomposing before melting at a tempreature of 200°C and as described in the study referred to.
Key result
Form:
solid: particulate/powder
Colour:
white
Substance type:
organic
Conclusions:
The physical state and appearance of the test item is a white solid/particulate at 20°C and 1013 hPa, based on the test item having no melting point and decomposing before melting at a tempereture of about 200°C, as described in the study referred to. The result is considered to be reliable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
GLP compliance:
yes (incl. QA statement)
Type of method:
capillary method

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(3,5-Dihydroxyphenyl)-1-oxo-2-(N-1-(4-methoxyphenyl)isopropylamino)ethane Hydrobromide
EC Number:
928-779-0
Molecular formula:
C18-H21-N-O4 x HBr
IUPAC Name:
1-(3,5-Dihydroxyphenyl)-1-oxo-2-(N-1-(4-methoxyphenyl)isopropylamino)ethane Hydrobromide
Test material form:
solid: particulate/powder

Results and discussion

Melting / freezing point
Key result
Decomposition:
yes
Decomp. temp.:
200 °C

Any other information on results incl. tables

In the preliminary capillary test accoring to OECD guideline 102 and EC method A.1. no melting point could be observed as the test substance started to decompose at a temperature of 200 °C. The test item began to change its color from white over yellow and light red to black at 200°C . This behavior of the test item leads to the conclusion that TH 1165 Keton I BR decomposes and has no melting point.

Applicant's summary and conclusion

Conclusions:
No melting point could be observed as the test item started to decompose at a temperature of 200 °C.