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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitrilotrimethylenetris(phosphonic acid)
EC Number:
229-146-5
EC Name:
Nitrilotrimethylenetris(phosphonic acid)
Cas Number:
6419-19-8
Molecular formula:
C3H12NO9P3
IUPAC Name:
[nitrilotris(methylene)]tris(phosphonic acid)
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Duration and frequency of treatment / exposure:
treatment was carried out once
Doses / concentrationsopen allclose all
Dose / conc.:
10 mg/kg bw/day
Dose / conc.:
50 mg/kg bw/day
No. of animals per sex per dose / concentration:
4M
Control animals:
no

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Intestinal absorption was found to be minimal based on the measurements of radioactivity from stomach/bowel and urine. At the 10mg/kg dose, 1.85% of the administered radioactivity was intestinally absorbed, and at the 50 mg/kg 2.01%.
Details on distribution in tissues:
The carcass and bones suggest that the test material may be bone-specific.
Details on excretion:
After oral administration of the test material, the largest amount of radioactivity was found in the faeces. The percentage excreted in the faeces is either not intestinally absorbed or intestinally absorbed and excreted as bile in faeces. In order to further investigate whether excretion is via bile a intravenous or subcutaneous application of test material is required.

Applicant's summary and conclusion

Conclusions:
The results suggest bone-specific bio-accumulation.