Registration Dossier
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EC number: 947-369-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No study of toxicity to micro-organisms is available for HMDTMP(4-7Na). A reliable study, performed with a Na/H salt of EDTMP, is available. The EC50 to WWTP micro-organisms was determined to be >100 mg active acid/L in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 100 mg/L
Additional information
In a study conducted with the sodium salt of EDTMP, according to OECD 209, 5.4% inhibition was seen at 100 mg/L loading (in terms of active acid), thus the EC50 is >100 mg active acid/L. No NOEC or EC5 was derived by the report authors, however in view of the low level of inhibition (approximately 5%) seen at a loading of 100 mg active acid/L, it is considered acceptable to interpret this concentration as an approximation of the EC5 for the purpose of PNEC derivation.
Both HMDTMP and EDTMP share a common chemistry incorporating alkyl backbones with one or more tertiary amine centres and multiple methylphosphonate groups present.
HMDTMP acid (CAS 23605-74-5) has two aminobismethylphosphonate groups, connected by a hexyl chain. EDTMP acid (CAS 1429-50-1) has two aminobismethylphosphonate groups, connected by an ethyl chain.
As well as being structural analogues, both phosphonates have consistent chemical properties including high MW (492 and 436 respectively), very low log Kow(≤-4 for both substances) and are highly soluble in water. The substances generally posses similar physico-chemical properties and are not readily biodegradable.
The sodium and potassium counterions of these phosphonates are not significant in respect of the properties under consideration and have been assessed in depth in the public literature. Additionally, the counterions are expected to dissociate when in contact with water, including atmospheric moisture.
Therefore, for the purpose of this assessment, read-across is considered valid. Further information on the analogue group and the validity of read-across are presented in the CSR Chapter 1.
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