Sodium salts of [hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid (4-7 Na:1)

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

Information on method and guideline not stated

GLP compliance:

not specified

Water solubility:

34 vol%

Temp.:

25 °C

pH:

6 - 8

Remarks on result:

other: This value is the weight by weight percent as sold on the market.

Key result

Water solubility:

>= 430 g/L

Temp.:

25 °C

pH:

ca. 6 - ca. 8

Remarks on result:

other: The source reports the substance as "soluble in water" This value has been derived by the reviewer and is equivalent to the above value in g/l. The temperature is not stated in the source but this has been assumed as ambient temperature.

Conclusions:

HMDTMP-xNa was reported as soluble in water at pH 6-8 (430 g/L). Full details are not available and the reliability is unassignable.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

Information on method and guideline not stated

GLP compliance:

no

Type of method:

other: Not reported

Key result

Water solubility:

15 000 mg/L

Remarks on result:

other: No information on pH and temperature stated

Conclusions:

HMDTMP-H was reported as very soluble in water in a secondary literature. The original reference was not available for review and no further information is available. The reliability of this result is not assignable.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

Information on method and guideline not stated

GLP compliance:

not specified

Water solubility:

30 - 40 vol%

Temp.:

25 °C

pH:

ca. 7

Remarks on result:

other: This value is the weight by weight percent as sold on the market. An average value of 35% was used by the reviewer.

Key result

Water solubility:

>= 440 g/L

Temp.:

25 °C

pH:

ca. 7

Remarks on result:

other: The source reported the solubility of the substance as "miscible in all proportions". This value has been derived by the reviewer and is equivalent to the above value in g/l. The temperature is not stated in the source but this has been assumed

Conclusions:

HMDTMP-xNa was reported as miscible in all proportions with water an pH ~7 (440 g/L). Full details are not available and the reliability is unassignable.

Reference 4

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

Information on method and guideline not stated

Water solubility:

30 vol%

Temp.:

20 °C

pH:

ca. 5.8 - ca. 6.3

Remarks on result:

other: This value is the weight by weight percent as sold on the market.

Key result

Water solubility:

>= 380 g/L

Temp.:

20 °C

pH:

ca. 5.8 - ca. 6.3

Remarks on result:

other: The source reported the solubility of the substance as "fully miscible with water". This value has been derived by the reviewer and is equivalent to the above value in g/l.

Conclusions:

HMDTMP-H was reported as fully miscible with water at a temperature of 20°C and pH of 5.8 - 6.3 (380 g/L). Full details are not available and the reliability is unassignable.

Description of key information

Water solubility [HMDTMP (4-7Na)]: The substance is very soluble in water and has an average water solubility value of 410 g/L at ambient conditions as described in a secondary sources.

Key value for chemical safety assessment

Water solubility:

410 g/L

at the temperature of:

25 °C

Additional information

The substance HMDTMP (4-7Na) (and its analogues) are known to be highly hydrophilic and extremely water-soluble. Although supplier's literature is much less detailed than laboratory study reports, given the range of values expected for these types of substance, the uncetainty is not significant in respect of environmental exposure or human health exposure modelling. Typical concentrations of aqueous solutions in commercial supply provides weight of evidence of high loadings. Water solubility in the range 380 - 440 g/L were reported for the sodium salt of HMDTMP. Therefore, a typical value of 410 g/L was determined for many commercial solutions.

Phosphonate salts are highly water soluble and are supplied as aqueous solutions. Free acids are less soluble than the salts; however, aqueous solutions in excess of l % active material can be prepared. The aqueous solution of sodium and potassium salts are miscible in water. A water solubility value of 15000 mg/L was reported for the parent acid in a secondary source to which no reliability could be assigned.