1,1,1,2,2,3,3-heptafluoro-3-[(trifluorovinyl)oxy]propane

Henry's Law constant

Administrative data

Endpoint:

Henry's law constant

Type of information:

experimental study

Adequacy of study:

key study

Study period:

31 Ocotober 2014 - 07 November 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail, study under GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The Henry's Law constant of PPVE was determined by the ratio of gas-phase concentration over aqueous phase concentration for a given test system vessel at equilibrium conditions and at ambient temperature and pressure. Gas phase and water phase aliquots were analyzed using purge and trap gas chromatography/mass spectrometry (GC/MS).

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

PPVE

IUPAC Name:

PPVE

Details on test material:

- Name of test material (as cited in study report): PPVE
- Substance type: Single component substance
- Physical state: Colorless, clear liquid at room temperature
- Analytical purity: 98.5%
- Storage condition of test material: Ambient temperature

Results and discussion

Henry's Law constant H

H:

3 200 dimensionless

Temp.:

22.6 °C

Atm. press.:

760 mm Hg

Remarks on result:

other: %RSD = 13

Any other information on results incl. tables

Table 1: Summary of Henry’s Law Constant (HLC) for PPVE

 

Ratio (Headspace: Aqueous)	Replicate	Time point 1 (Five days)	Time point 2 (Six days)	Time point 3 (Seven days)
70 % Headspace	1	3230	3320	3370
	2	3690	3130	3370
	Average	3460	3230	3370
	%RPD	13	5.9	0.25
50 % Headspace	1	3820	3060	2940
	2	3540	3090	3020
	Average	3680	3070	2980
	%RPD	7.4	1.0	2.5
30 % Headspace	1	3800	3460	2680
	2	2860	2840	2290
	Average	3330	3150	2490
	%RPD	28	20	16
Intra-Time Point Average % RSD		3490 11	3150 7.0	2950 14
Overall Average %RSD		3200 13

 

Table 2: Summary of Log (HLC) for PPVE

 

Ratio (Headspace: Aqueous)	Replicate	Time point 1 (Five days)	Time point 2 (Six days)	Time point 3 (Seven days)
70 % Headspace	1	3.5	3.5	3.5
	2	3.6	3.5	3.5
	Average	3.5	3.5	3.5
	%RPD	1.6	0.73	0.031
50 % Headspace	1	3.6	3.5	3.5
	2	3.5	3.5	3.5
	Average	3.6	3.5	3.5
	%RPD	0.90	0.59	0.32
30 % Headspace	1	3.6	3.5	3.4
	2	3.5	3.5	3.4
	Average	3.5	3.5	3.4
	%RPD	3.5	2.5	2.0
Intra-Day Average % RSD		3.5 1.4	3.5 0.95	3.5 1.8
Overall Average %RSD		3.5 1.6

Applicant's summary and conclusion

Conclusions:

The Henry's Law constant (HLC) for PPVE was determined based on measured concentrations in the gas-phase and aqueous-phase. Under an average study temperature of 22.6°C, the average HLC was 3200, the average log HLC was 3.5.

Executive summary:

The Henry's Law constant of PPVE was determined by the ratio of gas-phase concentration over aqueous-phase concentration.

Duplicate test vessels were filled with water and dosed with PPVE gas at three headspace:water ratios (70%, 50% and 30%). The vials were incubated for 5, 6, and 7 days at ambient temperature. Both the headspace and the water phase for each vial were sampled and analyzed in duplicates using gas chromatography/mass spectrometry (GC/MS). The average measured gas phase and water phase concentrations were used to calculate Henry's Law constant for PPVE for each test vessel. Under the conditions of this study (average temperature of 22.6°C), overall average HLC for PPVE is 3200 (%RSD = 13), the overall average log HLC was 3.5 ± 0.06 (% RSD= 1.6).

This study was conducted under GLP compliance with accepted method. Therefore, it is considered reliable without restrictions.