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EC number: 203-704-8 | CAS number: 109-78-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Directive EEC 79/831; Annex V; Part C: Biotic Degradation: Closed-Bottle-Test
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Principles of method if other than guideline:
- Method followed: Directive EEC 79/831; Annex V; Part C: Biotic Degradation: Closed-Bottle-Test, published in: O. J. (Official Journal of
the European Community) L251/3, 188-189 - GLP compliance:
- yes
Test material
- Reference substance name:
- 3-hydroxypropiononitrile
- EC Number:
- 203-704-8
- EC Name:
- 3-hydroxypropiononitrile
- Cas Number:
- 109-78-4
- Molecular formula:
- C3H5NO
- IUPAC Name:
- 3-hydroxypropanenitrile
- Details on test material:
- - Supplier: Röhm GmbH, Germany
- Analytical purity: 99.08%
- Storage condition of test material: cool, dark
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic, non-adapted
- Details on inoculum:
- Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Samples of
microorganisms of a secondary effluent were withdrawn from a sewage plant mainly fed with domestic sewage. - Duration of test (contact time):
- >= 28 d
Initial test substance concentration
- Initial conc.:
- 4.11 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: the test medium contained different mineral solutions, consisting of KH2PO4, K2HPO4,
Na2HPO4x2H20, NH4Cl at ph7.2 and MgSO4x 7 H2O, CaCl2, FeCl3 x 6 H2O.
- Test temperature: 20°C
- pH: 7.2
- Aeration of dilution water: for a period of about 20 hours
- Continuous darkness: yes
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 63.2
- Sampling time:
- 28 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 4.6
- Sampling time:
- 5 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 5.5
- Sampling time:
- 10 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 33.1
- Sampling time:
- 15 d
Any other information on results incl. tables
O2 consumption calc: Dt=[(mg BODx/1): (mg subs/1 x ThOD)]x100; Dt = Biodegradation at time t |
mtx= O2-conc. of the mineral nutrient solut. with test mat. and with inoculum at time x (average of two parallels). |
BODx = (mo-mtx)-(mo-mbx); mo= O2-conc of the mineral nutrient solut. without test material and without inoculum (average of two parallels)mbx = O2-conc of the mineral nutrient solut. without test material but with inoculum at time x (average of two parallels) |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- A degradation rate of 63% was obtained after 28 days, thus the test substance 2-Cyanoethanol has to be classificated as inherently biodegradable.
- Executive summary:
According to the measured values of O2 -concentrations (in dependance of time, x) in the test vessels (with/without test
material/inoculum) via O2 -electrode, was calculated the BODx (Biological Oxygen Demand, in dependance of time, x). Via the BODx,
the ThOD and the concentration of the test substance 2 -Cyanoethanol in solution, the biotic Degradation at time x was calculated. The
calculation of Dt, the biodegradation rate in time, was performed according to the following formula: Dt(%) = [(mg BODx /l) : (mg
Subst / l x ThOD)] x 100 Description of the curve of biodegradation (%): After a lag phase of about 10 days biodegradation takes
place. Within the following 10 days, after 10% biodegradation was exceeded, about 40% degradation was obtained. Finally, a
degradation rate of 63% was obtained. Since degradation time (28 days), belonging to the degradation rate of about > 60%, exceeded
the 10 days window, 2-Cyanoethanol has to be classificated according to the criteria of test evaluation as "inherently biodegradable".
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