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EC number: 259-869-1 | CAS number: 55860-53-2
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: earthworm
- Animal group:
- other: QSAR model
- Study type:
- other: QSAR
- Substrate type:
- other: QSAR
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Moisture:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : O(C(=NCC)S)CC(C)C
CHEM : Carbamothioic acid, ethyl-, o-(2-methylpropyl) ester
CAS Num: 55860-53-2
MOL FOR: C7 H15 N1 O1 S1
MOL WT : 161.26
Log Kow: 3.81 (KowWin estimate)
Wat Sol: 37.72 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 182.026 mg/kg soil ww
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
- Details on results:
- LC50 (14-day, earthworm)= 182.026 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=182.026 mg/kg soil dw - Reported statistics and error estimates:
- US EPA accepted QSAR method for chemicals properties assessment.
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- LC50 (14-day, earthworm)= 182.026 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=182.026 mg/kg soil dw - Executive summary:
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 182.026 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 182.026 mg/kg soil dw
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Data waiving:
- exposure considerations
- Justification for data waiving:
- the study does not need to be conducted because direct and indirect exposure of the soil compartment is unlikely
- Justification for type of information:
- In accordance with column 2 of REACH Annex IX, the toxicity to macroorganisms study does not need to be performed as the substance is highly unlikely to have any contact (exposure to) soil, either directly or indirectly.
Referenceopen allclose all
Overview of QSARs estimations on toxicity of O-isobutyl ethylthiocarbamate to soil macroorganisms
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
LC50 (14-day, earthworm)= 182.026 mg/L (ppm)
|
Reliable withrestrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
LC50 (14-day, earthworm)= 182.026 mg/kg soil dw
Description of key information
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm)would to be182.026mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 182.026 mg/kg soil dw
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 182.026 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 36.41 mg/kg soil dw
Additional information
According to “ANNEX IX- STANDARD INFORMATION REQUIREMENTS FOR SUBSTANCES MANUFACTURED OR IMPORTED IN QUANTITIES OF 100 TONNES OR MORE , study for effects on terrestrial organisms and plants need not be conducted if: - These studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely.
In accordance with column 2 of REACH Annex IX, the toxicity to macroorganisms study does not need to be performed as the substance is highly unlikely to have any contact (exposure to) soil, either directly or indirectly
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
