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Diss Factsheets
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EC number: 947-255-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, but considered sufficiently reliable for the purpose of hazard assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Camphor tree, ext.
- EC Number:
- 295-980-1
- EC Name:
- Camphor tree, ext.
- Cas Number:
- 92201-50-8
- IUPAC Name:
- Essential oil of Cinnamomum camphora (Lauraceae) obtained from fractional distillation of the decamphorized crude camphor oil
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Camphor oil
- Physical state: Clear yellow liquid
- Source: Research Institute for Fragrance Materials, Inc., USA
- Date of receipt: 05 May 1971
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-300 g
- Housing: Animals were individually housed
- Diet: Commercial diets, ad libitum
- Water: Water, ad libitum
- Fasting period before study: Overnight fasting
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Remarks:
- 50 % (w/v or v/v)
- Doses:
- 1 to 6.81 mL/kg bw
- No. of animals per sex per dose:
- 2 animals for the preliminary study
5 animals for the main study (LD50 determination) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Animals were observed for toxic signs and mortality at 1 and 4 h and once daily thereafter for for 14 days.
- Necropsy performed: Yes; gross necropsy was performed on any animal that died during the study and on survivors which were killed by cervical dislocation at termination and macroscopic examination was performed. - Statistics:
- - LD50 value was calculated according to Horn's method.
Results and discussion
- Preliminary study:
- at 5000 mg/kg bw, 2/2 rats died.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 730 - 7 470
- Mortality:
- No detail on the mortality in the main test
- Clinical signs:
- other: - Toxic signs observed were bloody crust eyes and nose, dyspnea, depression and ataxia.
- Gross pathology:
- - At ≥2.15 mL/kg bw, the dead rats had darkened lungs and gas and fluid in gastrointestinal tract.
- No gross lesions were observed in animals killed at termination. - Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the oral LD50 for Camphor oil is 5100 mg/kg bw (C.I. 2730-7470) in rats therefore it is not classified according to the Regulation (EC) No.1272/2008 (CLP) and GHS.
- Executive summary:
In an acute oral toxicity study, a preliminary test was performed on two rats with a single dose of Camphor oil at 5000 mg/kg bw. Mortality was observed in 2/2 animals. Therefore the LD50 was determined in further animals (6 groups of 5 rats/dose). The rats were given a single oral dose of Camphor oil at 1 to 6.81 mL/kg bw. Animals were then observed for mortality and clinical signs for 14 days and were all sacrificed for macroscopic examination.
Toxic signs observed were bloody crust eyes and nose, dyspnea, depression and ataxia. At ≥2.15 mL/kg bw, the dead rats had darkened lungs and gas and fluid in gastrointestinal tract. No gross lesions were observed in animals killed at termination. In this study, the oral LD50 of test item was calculated to be 5100 mg/kg bw (C.I. 2730 -7470) in rats by the Horn's method.
Under the test conditions, the oral LD50 for the registered substance is 5100 mg/kg bw (C.I. 2730 -7470) in rats therefore it is not classified according to the Regulation (EC) No. 1272/2008 (CLP) and GHS.
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