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EC number: 230-991-7 | CAS number: 7397-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- September 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert judgement
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Expert judgement
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline available
Test material
- Reference substance name:
- Butyl glycollate
- EC Number:
- 230-991-7
- EC Name:
- Butyl glycollate
- Cas Number:
- 7397-62-8
- Molecular formula:
- C6H12O3
- IUPAC Name:
- butyl glycolate
- Reference substance name:
- Polysolvan O
- IUPAC Name:
- Polysolvan O
- Reference substance name:
- Glycolic acid-n-butyl ester
- IUPAC Name:
- Glycolic acid-n-butyl ester
- Details on test material:
- not applicable
Constituent 1
Constituent 2
Constituent 3
- Radiolabelling:
- other: not applicable
Administration / exposure
- Duration of exposure:
- not applicable
- Doses:
- not applicable
- No. of animals per group:
- not applicable
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption is suggested to amount to about 10% followed by wide-spread distribution and rapid elimination with regards to the log Pow of Butyl glycollate (Polysolvan O) of 0.38, the data on the hydrolysis products and compounds with comparable log Pows.
- Executive summary:
Expert judgement on dermal absorption
No in vitro or in vivo studies are available on dermal absorption of Butyl glycollate (Polysolvan O).
With regards to dermal penetration and in case of missing data, the physical chemical properties and especially the log Pow provide valuable information on possible skin penetration behaviour. The log Pow of Butyl glycollate (Polysolvan O) is 0.38, which indicates a hydrophobic behaviour most probably due to the polar structure of the molecule. Compounds with a similar log Pow as e.g. 2-butoxyethanol (BE, butyl glycol, CAS 111-76-2, log Pow 0.81) are known to penetrate sufficiently through the skin. However, BE is chemically an ether, slightly more hydrophobic and therefore will penetrate much better than Butyl glycollate (Polysolvan O). Interestingly, its vapour pressure of 1.17 hPa is also very low (OECD, 1997). In addition, the log Pow of the breakdown product n-butyl alcohol (BA) is 0.88 and thus in the same order as Butyl glycollate (Polysolvan O), while the other breakdown product glycolic acid (GA) has a log Pow -1.11. BA is known to be readily absorbed through the skin. For GA a comprehensive data base on dermal penetration is available, which indicated that the penetration behaviour depends also on pH and composition of formulation. Generally, the observed skin penetration rates of GA ranged between about 2 – 30%, with higher penetration at lower pH. Finally, considering the slightly acidic physiological skin pH in the range of 5 -6 and with regards to the Log Pow, physical chemical properties and data on its principle metabolites, the dermal penetration of Butyl glycollate (Polysolvan O) is assumed as 10%. With regards to the activity of esterases in the skin as well as systemically in the body, the toxicokinetics and metabolic fate is considered as comparable as after oral intake.
Conclusions
The dermal absorption is suggested to amount to about 10% followed by wide-spread distribution and rapid elimination with regards to the log Pow of Butyl glycollate (Polysolvan O) of 0.38, the data on the hydrolysis products and compounds with comparable log Pows.
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