Registration Dossier
Registration Dossier
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EC number: 947-360-3 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From January 9, 2015 to April 10, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- flask method
- Specific details on test material used for the study:
- Batch no.: SEALS 2011-104-06-01
Appearance: solid - Key result
- Water solubility:
- 1 503 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 g/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 6.6
- Conclusions:
- Under the study conditions, the water solubility of the test substance was determined to be 1503 ± 70 mg/L at 20°C.
- Executive summary:
A study was conducted to determine the water solubility of the test substance according to EU Method A.6 (flask method). About 0.5 g of the test substance was suspended in 100 mL deionised water and stirred in a heated water bath at 30°C for 24, 48 and 72h, respectively. After incubation, the sample suspensions were cooled to 20°C and kept at this temperature for 24h without stirring. Afterwards, the samples were centrifuged (3,500 U/min) at 20°C for 30 min. The still cloudy water phases were filtrated and then analysed by liquid chromatography. Under the study conditions, the water solubility of the test substance was determined to be 1503 ± 70 mg/L at 20°C (Schwarzkopf, 2015).
Reference
Table 3: Solubilities determined at different incubation times at 20°C
Incubation time (hours) |
Water solubility (g/L) |
Average (g/L) |
24 |
1.423 |
1.503 ± 0.07 |
48 |
1.535 |
|
72 |
1.552 |
Description of key information
The water solubility was determined according to EU Method A.6 (flask method) (Schwarzkopf, 2015)
Key value for chemical safety assessment
- Water solubility:
- 1 503 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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