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Diss Factsheets
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EC number: 217-576-6 | CAS number: 1892-29-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The test item was considered not toxic to waste water bacteria (activated sludge) at or below a concentration of 3.2 mg/L, which was considered as the NOEC. The 3 hour EC50 was determined to be 612 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 612 mg/L
- EC10 or NOEC for microorganisms:
- 3.2 mg/L
Additional information
Charles River Laboratories (2017) is a GLP compliant study following OECD guideline 209 and is therefore considered reliable without restrictions (Klimisch 1). The mean control oxygen uptake rate exceeded 20 mg per 1 g of activated sludge in an hour (26 mg oxygen). The coefficient of variation of oxygen uptake in the control replicates did not exceed 30% at the end of the definitive test (13%). The criteria for acceptability of the test were met, therefore, the study was deemed as valid. A combined range-finding and limit test were conducted with the concentrations 10, 100 and 1000 mg/L. A control (6 replicates) and an abiotic control (1 replicate) were tested. The pH of the sludge was 7.2 on the day of testing. The combined limit/range-finding test results displayed 10% inhibition of the respiration rate at 10 mg/L, 39% at 100 mg/L and 63% at 1000 mg test item per litre. It was therefore expected that the EC50 was between 100 and 1000 mg/L. For the final test, nominal concentrations of 1.0, 3.2, 10, 32, 100, 320 and 1000 mg/L were used. 5 replicates were used per test group and 6 replicates were used for the control. In conclusion, the study showed that the test item was considered non-toxic to the activated sludge (waste water bacteria) at and above the concentration of 3.2 mg/L (NOEC). The 3 hour EC50 was determined to be 612 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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