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Diss Factsheets
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EC number: 280-518-3 | CAS number: 83682-78-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 48 hours
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Performed to OECD guidelines to GLP in 2016.
Analysis performed to verify dose levels - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- COCAMIDOPROPYL PG - DIMONIUM CHLORIDE PHOSPHATELOT # 50113A16
Date 07 Mar 16;Physical Description: Clear liquid
Storage Conditions: Room temperature
Purity: 41% active ingredient
Stability: Not provided to testing facility - Analytical monitoring:
- yes
- Details on sampling:
- Dose verification was performed during the study on test solutions sampled at 0 and 48 hours for therange-finding and definitive tests
- Vehicle:
- no
- Details on test solutions:
- Readily soluble in water
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magnaSource: STILLMEADOW, Inc. culture laboratory
Age: No greater than 24 hours old at dosing; - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Total hardness 200 mg/L CaCO3
- Test temperature:
- 20 C
- pH:
- pH 7.9
- Dissolved oxygen:
- 60 - 100% saturation
- Nominal and measured concentrations:
- Range-finding concentrations of 0.01, 0.1, 1, 10 and 100 mg/l a.i.
Definitive 0, 0.625, 1.25, 2.5, 5.0, 10.0 mg/l ai - Details on test conditions:
- 250 mL glass beakers; filled with 200 ml of the appropriate solution
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 5.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- ca. 0.625 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- Nominal concentrations are reported, based on active component
- Validity criteria fulfilled:
- yes
- Conclusions:
- Crude analysis was performed to verify dose levels; since the substance is functionally stable in water and highly soluble, this minimal analysis is not considered sufficient to confirm exposure. Nominal concentrations are cited. A good dose-response relationship was seen with the highest concentrations resulting in 100% immobilisaiton and the lowest having no effect. The EC50 is clearly in the range 1 - 10 mg/l for purposes of classification
- Executive summary:
A good dose-response relationship was seen with the highest concentrations resulting in 100% immobilisaiton and the lowest having no effect. The EC50 is clearly in the range 1 - 10 mg/l for purposes of classification
Reference
Description of key information
A good dose-response relationship was seen with the highest concentrations resulting in 100% immobilisaiton and the lowest having no effect. The EC50 is clearly in the range 1 - 10 mg/l for purposes of classification
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.